Dog Apolipoprotein E (APOE) Protein

Este producto es parte de APOE - Apolipoprotein E
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468€ (50 µg)

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935106861
info@markelab.com
name
Dog Apolipoprotein E (APOE) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168028
tested applications
WB, SDS-PAGE

Description

Apolipoprotein E Protein is a recombinant Dog protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Apolipoprotein E (APOE)
Host
E. coli
Origin
Dog
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 23.7 kDa  Observed MW (SDS-PAGE): 24 kDa

Concentration: Prior to lyophilization: 500 µg/ml

Sequence Fragment: Asp1-Val172

Tag: N-terminal His tag
Expression
Recombinant
Purity
> 95%
Size 1
50 µg
Size 2
100 µg
Size 3
200 µg
Size 4
500 µg
Size 5
1 mg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
APOE, AD2, APO-E, LDLCQ5, LPG, apolipoprotein E, ApoE4, Apo E
Background
Protein APOE
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Apolipoprotein E (APOE) is a critical glycoprotein involved in lipid metabolism, lipid transport, and cholesterol homeostasis. ApoE is synthesized primarily in the liver, brain, and adipose tissue and is a major component of chylomicron remnants, VLDL, and HDL particles. It facilitates the clearance of triglyceride-rich lipoproteins by binding to specific receptors, including the low-density lipoprotein receptor (LDLR) and LRP1, enabling lipoprotein uptake in the liver. ApoE plays a significant role in reverse cholesterol transport, promoting the efflux of cholesterol from peripheral tissues to the liver for excretion. ApoE exists in three common isoforms – ApoE2, ApoE3, and ApoE4 – which influence lipid metabolism and disease risk. The ApoE4 allele is a major genetic risk factor for Alzheimer’s disease, as it impairs beta-amyloid clearance and exacerbates neurodegeneration. ApoE is also implicated in atherosclerosis, cardiovascular disease, and type 2 diabetes due to its role in lipid transport and inflammation. ApoE regulates immune function and inflammatory responses, contributing to tissue repair and maintenance. Therapeutic strategies targeting ApoE pathways, such as receptor modulators and lipid-lowering therapies, are under investigation for their potential in treating neurodegenerative and cardiovascular diseases. ApoE’s pleiotropic effects on lipid metabolism, brain health, and immune regulation underscore its importance as a key protein in human physiology.

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