APBB1IP - Amyloid beta A4 precursor protein-binding family B member 1-interacting protein | Elisa - Clia - Antibody - Protein
Family main features
Background
APBB1IP, also known as Rap1-GTP-interacting adapter molecule (RIAM), is a crucial protein involved in integrin activation and signal transduction pathways. It belongs to the MRL (Mig-10/RIAM/Lamellipodin) family of adaptor proteins, which play significant roles in cell migration and adhesion. The protein is expressed in various tissues, particularly in hematopoietic cells, and is vital for the proper functioning of the immune system. APBB1IP facilitates the linkage between Ras-related protein 1 (Rap1) and integrins, which are essential for the regulation of cell adhesion and migration. This protein is implicated in various physiological processes, including immune cell trafficking, platelet aggregation, and cardiovascular homeostasis.
Protein Structure
APBB1IP is composed of several key domains that facilitate its function:
- N-terminal Ras association (RA) domain: This domain is responsible for binding to active Rap1-GTP, crucial for its role in integrin activation.
- Proline-rich regions (PRRs): These regions mediate interactions with SH3 domain-containing proteins, allowing for the formation of protein complexes necessary for signal transduction.
- Plekstrin homology (PH) domain: This domain binds to phosphoinositides in cell membranes, anchoring APBB1IP to specific cellular locations.
- Coiled-coil domain: Facilitates protein-protein interactions, crucial for its adaptor functions. These structural components enable APBB1IP to interact with multiple proteins and phospholipids, playing a vital role in cellular adhesion and migration mechanisms.
Classification and Subtypes
APBB1IP is classified within the MRL family of proteins, which are characterized by their roles in cellular migration and adhesion. There are no well-defined subtypes of APBB1IP itself, but it shares functional similarities with other MRL family members, such as Lamellipodin and Mig-10, which also participate in actin cytoskeleton remodeling and cell migration.
Function and Biological Significance
APBB1IP is integral to several cellular functions:
- Integrin Activation: APBB1IP mediates the activation of integrins, which are essential for cell adhesion and migration. This is crucial in immune responses where leukocytes need to adhere to and migrate through the endothelium.
- Cell Migration: Through its interaction with Rap1 and actin cytoskeleton, APBB1IP plays a pivotal role in cell motility, aiding processes like wound healing and immune surveillance.
- Signal Transduction: Acts as an adaptor linking small GTPases like Rap1 to downstream signaling pathways, influencing cellular responses to extracellular stimuli.
- Platelet Aggregation: Essential for the proper functioning of platelets during blood clotting processes.
Clinical Issues
Dysfunction or altered expression of APBB1IP is linked to various clinical conditions:
- Immune Disorders: Impaired function of APBB1IP can lead to defects in leukocyte adhesion and migration, potentially resulting in immune deficiencies.
- Cardiovascular Diseases: Abnormalities in integrin signaling mediated by APBB1IP can contribute to cardiovascular diseases, including atherosclerosis and thrombosis.
- Cancer: Aberrant expression or mutation of APBB1IP can affect tumor cell migration and invasion, influencing cancer metastasis.
Summary
APBB1IP is a critical adaptor protein that facilitates integrin activation and cell migration by linking Rap1-GTP to downstream signaling pathways. Its structural domains enable it to interact with various proteins and phospholipids, playing essential roles in immune responses, platelet aggregation, and cell motility. Dysregulation of APBB1IP is associated with several diseases, including immune disorders, cardiovascular diseases, and cancer. Understanding the function and regulation of APBB1IP can provide insights into potential therapeutic targets for these conditions.
APBB1IP Recommended name:
Amyloid Beta A4 Precursor Protein-Binding Family B Member 1-Interacting Protein (APBB1IP)
Aliases for APBB1IP
APBB1IP, INAG1, PREL1, RARP1, RIAM,Rap1-GTP-interacting adapter molecule
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits) relacionados con APBB1IP - Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
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immunoassays
| provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Abbexa | APBB1IP | abx500392 | Human Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1IP) ELISA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | 0.156 ng/ml - 10 ng/ml | 715 | 96 tests | Q7Z5R6 | RUO | ||
| Abbexa | APBB1IP | abx500393 | Mouse Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1IP) ELISA Kit | Mouse | Tissue homogenates, cell lysates and other biological fluids. | 0.156 ng/ml - 10 ng/ml | 715 | 96 tests | Q8R5A3 | RUO |
Primary Antibodies
| provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FineTest | APBB1IP | FNab07291 | anti- RIAM antibody | human | polyclonal | Rabbit | amyloid beta(A4) precursor protein-binding, family B, member 1 interacting protein | IgG | Unconjugated | ELISA, WB, IHC, IP | 100µg | Q7Z5R6 | RUO | |
| Abbexa | APBB1IP | abx456481 | Amyloid Beta A4 Precursor Protein-Binding Family B Member 1-Interacting Protein (APBB1IP) Antibody | Human | Polyclonal | Rabbit | Amyloid Beta A4 Precursor Protein-Binding Family B Member 1-Interacting Protein (APBB1IP) | IgG | Unconjugated | ELISA, WB, IHC | 260 | 50 µg | Q7Z5R6 | RUO |
| Abbexa | APBB1IP | abx128126 | Amyloid Beta Precursor Protein Binding B1 Interacting Protein (APBB1IP) Antibody | Human | Polyclonal | Rabbit | Amyloid Beta Precursor Protein Binding B1 Interacting Protein (APBB1IP) | Unconjugated | WB, IHC, IF/ICC | 299 | 100 µl | RUO | ||
| Abbexa | APBB1IP | abx224113 | Amyloid Beta A4 Precursor Protein-Binding Family B Member 1-Interacting Protein (APBB1IP) Antibody | Human | Monoclonal | Mouse | Amyloid Beta A4 Precursor Protein-Binding Family B Member 1-Interacting Protein (APBB1IP) | IgG1 | ELISA, IHC, FCM | 383.5 | 100 µl | Q7Z5R6 | RUO | |
| Abbexa | APBB1IP | abx016129 | Amyloid Beta A4 Precursor Protein-Binding Family B Member 1-Interacting Protein (APBB1IP) Antibody | Human | Monoclonal | Mouse | Amyloid Beta A4 Precursor Protein-Binding Family B Member 1-Interacting Protein (APBB1IP) | IgG1 | Unconjugated | ELISA, FCM | 383.5 | 100 µl | Q7Z5R6 | RUO |
| Abbexa | APBB1IP | abx323464 | Amyloid Beta Precursor Protein Binding Family B Member 1 Interacting Protein (APBB1IP) Antibody | Human | Polyclonal | Rabbit | Amyloid Beta Precursor Protein Binding Family B Member 1 Interacting Protein (APBB1IP) | IgG | Unconjugated | ELISA, WB | 221 | 50 µg | Q7Z5R6 | RUO |
| Abbexa | APBB1IP | abx237291 | Amyloid Beta A4 Precursor Protein-Binding Family B Member 1-Interacting Protein (APBB1IP) Antibody | Human | Polyclonal | Rabbit | Amyloid Beta A4 Precursor Protein-Binding Family B Member 1-Interacting Protein (APBB1IP) | IgG | Unconjugated | ELISA, WB, IHC, IP | 364 | 100 µg | Q7Z5R6 | RUO |
| Abbexa | APBB1IP | abx110957 | Amyloid Beta A4 Precursor Protein-Binding Family B Member 1-Interacting Protein (APBB1IP) Antibody | Human | Polyclonal | Rabbit | Amyloid Beta A4 Precursor Protein-Binding Family B Member 1-Interacting Protein (APBB1IP) | IgG | Unconjugated | ELISA, WB, IHC | 637 | 100 µl | Q7Z5R6 | RUO |
| Abbexa | APBB1IP | abx322718 | Amyloid Beta A4 Precursor Protein-Binding Family B Member 1-Interacting Protein (APBB1IP) Antibody | Human | Polyclonal | Rabbit | Amyloid Beta A4 Precursor Protein-Binding Family B Member 1-Interacting Protein (APBB1IP) | IgG | Unconjugated | ELISA, WB, IHC | 169 | 20 µl | Q7Z5R6 | RUO |
Proteins and Peptides
| provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Abbexa | APBB1IP | abx166079 | Human Amyloid Beta Precursor Protein Binding B1 Interacting Protein (APBB1IP) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 221 | 10 µg | Q9Y2B4 | RUO |
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