Family main features
Alpha-1-syntrophin (SNTA1) is a cytoplasmic adaptor protein that plays a crucial role in linking the actin cytoskeleton to the extracellular matrix, particularly in muscle tissues. SNTA1 is a member of the syntrophin family, which includes three isoforms: alpha, beta, and gamma. These proteins are associated with the dystrophin-glycoprotein complex (DGC), a multi-protein assembly critical for maintaining muscle integrity and function. SNTA1 is expressed in various tissues, including skeletal muscle, cardiac muscle, and neurons, indicating its diverse physiological roles. The DGC links the intracellular cytoskeleton to the extracellular matrix, providing mechanical stability and signaling functions essential for muscle function.
The structure of SNTA1 includes several distinct domains:
Syntrophins, including SNTA1, are classified into three main isoforms based on their sequence and structural similarities:
SNTA1 is involved in several critical cellular processes:
Dysregulation or mutations in SNTA1 and its associated pathways can lead to several clinical conditions:
Alpha-1-syntrophin (SNTA1) is a vital adaptor protein that connects the actin cytoskeleton to the extracellular matrix via the dystrophin-glycoprotein complex (DGC), primarily in muscle tissues. Its structure includes PH, PDZ, SU, and SB domains, which facilitate various protein-protein interactions crucial for maintaining muscle integrity and function. SNTA1 is involved in structural support, signal transduction, neuronal function, and cell membrane stabilization. Dysregulation or mutations in SNTA1 are associated with muscular dystrophy, cardiac arrhythmias, and neurological disorders, highlighting its significance in maintaining cellular homeostasis and function. Understanding SNTA1's roles and mechanisms is essential for developing therapeutic strategies for related diseases.
Alpha-1-syntrophin (SNTA1)
SNTA1, LQT12, SNT1, TACIP1, dJ1187J4.5, Syntrophin, alpha 1, syntrophin alpha 1
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits) relacionados con SNTA1 - Alpha-1-syntrophin
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 6 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | SNTA1 | abx385462 | Human Alpha-1-syntrophin (SNTA1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 687.5 | 96 tests | Q13424 | RUO |
Abbexa | SNTA1 | abx390698 | Mouse Alpha-1-syntrophin (SNTA1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 687.5 | 96 tests | Q61234 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | SNTA1 | abx137461 | Alpha-1-syntrophin (SNTA1) Antibody | Human | Monoclonal | Mouse | Alpha-1-syntrophin (SNTA1) | Unconjugated | 225 | 5 µg | RUO | |||
Abbexa | SNTA1 | abx211870 | Alpha-1-syntrophin (SNTA1) Antibody | Human | Polyclonal | Rabbit | Alpha-1-syntrophin (SNTA1) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | Q13424 | RUO | |
Abbexa | SNTA1 | abx211869 | Alpha-1-syntrophin (SNTA1) Antibody | Human | Polyclonal | Rabbit | Alpha-1-syntrophin (SNTA1) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | Q13424 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | SNTA1 | abx262487 | Syntrophin, alpha 1 Protein | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | Q13424 | RUO |
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