ADAM17 - ADAM metallopeptidase domain 17| Elisa - Clia - Antibody - Protein

Family main features


Background

ADAM17, also known as ADAM metallopeptidase domain 17 or tumor necrosis factor-alpha converting enzyme (TACE), is a member of the ADAM family of proteins. Like other ADAM proteins, it possesses a complex domain structure with distinct functional regions, including a metalloproteinase domain responsible for its proteolytic activity.ADAM17 is a transmembrane protein. Consists of several domains, including a metalloproteinase domain, a disintegrin domain, a cysteine-rich domain, an EGF-like domain, a transmembrane domain, and a cytoplasmic tail. Is responsible for the cleavage and release of various membrane-bound proteins, including cytokines, growth factors, receptors, and adhesion molecules. One of its most well-known substrates is tumor necrosis factor-alpha (TNF-α).ADAM17 cleaves the membrane-bound precursor form of TNF-α to release its soluble form into the extracellular space. Soluble TNF-α can then bind to its receptors on target cells, initiating signaling cascades involved in inflammation, apoptosis, and immune responses.ADAM17 also sheds and regulates the activity of other important proteins, including epidermal growth factor receptor (EGFR) ligands, transforming growth factor-alpha (TGF-α), and Notch receptor. Dysregulation of ADAM17 activity has been implicated in various diseases, including inflammatory disorders, autoimmune diseases, cancer, and cardiovascular diseases. In particular, increased ADAM17 activity and elevated levels of its substrates, such as TNF-α, have been observed in conditions like rheumatoid arthritis, inflammatory bowel disease, and certain cancers. Given its central role in inflammation and disease pathogenesis, ADAM17 is considered a promising therapeutic target


Protein Structure

ADAM17 has a complex multi-domain structure typical of ADAM proteins:

  • Signal Peptide: Directs the protein to the secretory pathway.
  • Prodomain: Maintains the enzyme in an inactive form until it reaches its proper cellular location and is cleaved off to activate the enzyme.
  • Metalloprotease Domain: Contains the catalytic site with a zinc-binding motif essential for its proteolytic function.
  • Disintegrin Domain: Facilitates interactions with integrins and other cell surface receptors, contributing to cell adhesion and signaling.
  • Cysteine-Rich Domain: Contributes to the protein’s stability and interactions.
  • EGF-Like Domain: Participates in protein-protein interactions.
  • Transmembrane Domain: Anchors the protein in the cell membrane.
  • Cytoplasmic Tail: Involved in intracellular signaling and interactions with cytoskeletal elements.


Classification and Subtypes

ADAM17 belongs to the ADAM family, which includes proteins with both metalloprotease and disintegrin domains. It is specifically classified under metalloproteases due to its catalytic activity in proteolysis.


Function and Biological Significance

ADAM17 performs several critical functions:

  1. Proteolysis: The metalloprotease domain is responsible for cleaving the ectodomains of various transmembrane proteins, a process known as "shedding."
  2. Cytokine Release: ADAM17 is well-known for its role in releasing the extracellular domain of Tumor Necrosis Factor-α (TNF-α), a key cytokine in inflammation.
  3. Growth Factor Activation: Activates several growth factors, including transforming growth factor-alpha (TGF-α) and heparin-binding EGF-like growth factor (HB-EGF), by shedding their membrane-bound precursors.
  4. Cell Signaling: Modulates signaling pathways by shedding receptors and ligands, influencing processes like cell proliferation, migration, and apoptosis.
  5. Development: Involved in embryonic development and tissue remodeling by regulating the availability of growth factors and cytokines.


Interactions

ADAM17 interacts with various proteins and cellular components:

  1. Cytokine Precursors: Cleaves precursors of cytokines such as TNF-α, facilitating their release and activity.
  2. Growth Factor Precursors: Activates growth factors by cleaving their membrane-bound precursors.
  3. Integrins: The disintegrin domain mediates interactions with integrins, affecting cell adhesion and signaling.
  4. Cell Surface Receptors: Shedding of receptors like the IL-6 receptor, TNF receptors, and EGFR ligands, modulating their activity and downstream signaling.


Clinical Significance

The function and regulation of ADAM17 have significant implications in various diseases and conditions:

  1. Inflammatory Diseases: ADAM17 is a key mediator in the release of TNF-α and other pro-inflammatory cytokines, playing a critical role in conditions like rheumatoid arthritis and inflammatory bowel disease.
  2. Cancer: Dysregulated ADAM17 activity is implicated in cancer progression and metastasis through its role in shedding growth factors and receptors, promoting cell proliferation, migration, and survival.
  3. Cardiovascular Diseases: ADAM17 contributes to cardiovascular pathology by modulating inflammatory responses and affecting the shedding of receptors involved in vascular homeostasis.
  4. Fibrosis: Involved in tissue remodeling processes that can lead to fibrosis, making it a potential target for antifibrotic therapies.
  5. Neurodegenerative Diseases: Altered ADAM17 activity has been linked to neuroinflammation and the progression of diseases like Alzheimer's.


Summary

ADAM17, a member of the ADAM family, is crucial for processes such as proteolysis, cytokine release, growth factor activation, cell signaling, and development. It has a multi-domain structure, including a metalloprotease domain for proteolytic activity and a disintegrin domain for cell adhesion. ADAM17 interacts with cytokine and growth factor precursors, integrins, and cell surface receptors. Clinically, ADAM17 is significant in the context of inflammatory diseases, cancer, cardiovascular diseases, fibrosis, and neurodegenerative diseases. Understanding its structure, function, interactions, and clinical implications provides valuable insights into its role in cellular processes and potential as a therapeutic target.



ADAM17 Recommended name:

ADAM metallopeptidase domain 17(ADAM17)

Aliases for ADAM17

CSVP, CD156B, TACE,TNF-Alpha Convertase,TNF-Alpha Converting enzyme,adam-17

En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con ADAM17 - ADAM metallopeptidase domain 17

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immunoassays

providerCodereferencenamereactivitysample typeassay typetest rangesensitivitypricesize 1uniprot idstatus
AbbexaADAM17abx356703Chicken ADAM Metallopeptidase Domain 17 (ADAM17) ELISA KitChickenSerum, plasma and other biological fluids.Sandwich3.125 ng/ml - 200 ng/ml1.88 ng/ml68996 testsRUO
FineTestADAM17EH1488Human ADAM17(Disintegrin and metalloproteinase domain-containing protein 17) ELISA KithumanSerum,Plasma,Tissue homogenates,Other biological fluidsSandwich ELISA, Double Antibody62.5-4000pg/ml96TP78536RUO
AbbexaADAM17abx570602Human ADAM Metallopeptidase Domain 17 (ADAM17) ELISA KitHumanTissue homogenates, cell lysates and other biological fluids.Sandwich62.5 pg/ml - 4000 pg/ml37.5 pg/ml54696 testsP78536RUO
AbbexaADAM17abx150545Human ADAM Metallopeptidase Domain 17 (ADAM17) ELISA KitHumanSerum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml< 0.06 ng/ml55996 testsP78536RUO
AbbexaADAM17abx492863Human ADAM Metallopeptidase Domain 17 (ADAM17) CLIA KitHumanTissue homogenates, cell lysates and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml< 0.060 ng/ml84596 testsP78536RUO
FineTestADAM17EM1919Mouse adam17 (Disintegrin and metalloproteinase domain-containing protein 17) ELISA KitmouseSerum,Plasma,Tissue homogenates,Other biological fluidsSandwich ELISA, Double Antibody78.125-5000pg/ml96TQ9Z0F8RUO
AbbexaADAM17abx492864Mouse ADAM Metallopeptidase Domain 17 (ADAM17) CLIA KitMouseTissue homogenates, cell lysates and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml< 0.054 ng/ml84596 testsRUO
AbbexaADAM17abx258492Mouse ADAM Metallopeptidase Domain 17 (ADAM17) ELISA KitMouseTissue homogenates, cell lysates and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml< 0.06 ng/ml643.596 testsRUO
AbbexaADAM17abx361925Pig ADAM Metallopeptidase Domain 17 (ADAM17) ELISA KitPigTissue homogenates, cell lysates and other biological fluids.Sandwich62.5 pg/ml - 4000 pg/ml37.5 pg/ml71596 testsRUO
AbbexaADAM17abx155142Rat ADAM Metallopeptidase Domain 17 (ADAM17) ELISA KitRatTissue homogenates, cell lysates and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml< 0.07 ng/ml71596 testsQ9Z1K9RUO
AbbexaADAM17abx572869Rat ADAM Metallopeptidase Domain 17 (ADAM17) ELISA KitRatSerum, plasma and other biological fluids.Sandwich78.13 pg/ml - 5000 pg/ml46.88 pg/ml61196 testsRUO
AbbexaADAM17abx492865Rat ADAM Metallopeptidase Domain 17 (ADAM17) CLIA KitRatTissue homogenates, cell lysates and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml< 0.061 ng/ml84596 testsQ9Z1K9RUO

Primary Antibodies

providerCodereferencenamereactivityclonalityhostimmunogen targetisotypeconjugationtested applicationspricesize 1uniprot idstatus
FineTestADAM17FNab00139anti- ADAM17-Specific antibodyhumanpolyclonalRabbitADAM metallopeptidase domain 17IgGUnconjugatedELISA, WB100µgP78536RUO
FineTestADAM17FNab10431anti- ADAM17 antibodyhumanpolyclonalRabbitADAM metallopeptidase domain 17IgGUnconjugatedELISA, WB, IHC100µgP78536RUO
FineTestADAM17FNab00138anti- ADAM17 antibodyhumanpolyclonalRabbitADAM metallopeptidase domain 17IgGUnconjugatedELISA, WB, IHC100µgP78536RUO
AbbexaADAM17abx412493ADAM Metallopeptidase Domain 17 (ADAM17) AntibodyHumanPolyclonalRabbitADAM Metallopeptidase Domain 17 (ADAM17)IgGUnconjugatedWB455100 µgP78536RUO
AbbexaADAM17abx103981A Disintegrin And Metalloprotease 17 (ADAM17) AntibodyHumanPolyclonalRabbitA Disintegrin And Metalloprotease 17 (ADAM17)UnconjugatedWB, IHC, IF/ICC234100 µlP78536RUO
AbbexaADAM17abx272154A Disintegrin And Metalloprotease 17 (ADAM17) Antibody (Biotin)HumanPolyclonalRabbitA Disintegrin And Metalloprotease 17 (ADAM17)IgGBiotinWB, IHC, IF/ICC312200 µlRUO
AbbexaADAM17abx270145A Disintegrin And Metalloprotease 17 (ADAM17) AntibodyHumanMonoclonalMouseA Disintegrin And Metalloprotease 17 (ADAM17)IgGUnconjugatedFCM28650 testsRUO
AbbexaADAM17abx421177Disintegrin And Metalloproteinase Domain-Containing Protein 17 (ADAM17) AntibodyHumanMonoclonalMouseDisintegrin And Metalloproteinase Domain-Containing Protein 17 (ADAM17)IgG1 KappaUnconjugatedFCM31250 µgP78536RUO
AbbexaADAM17abx402408Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) AntibodyHumanMonoclonalRabbitDisintegrin and metalloproteinase domain-containing protein 17 (ADAM17)IgGUnconjugatedELISA, IF/ICC29950 µlP78536RUO
AbbexaADAM17abx270443A Disintegrin And Metalloprotease 17 (ADAM17) Antibody (FITC)HumanMonoclonalMouseA Disintegrin And Metalloprotease 17 (ADAM17)IgGFITCFCM494100 testsRUO
AbbexaADAM17abx455718Disintegrin And Metalloproteinase Domain-Containing Protein 17 (ADAM17) AntibodyHumanPolyclonalRabbitDisintegrin And Metalloproteinase Domain-Containing Protein 17 (ADAM17)IgGUnconjugatedELISA, WB, IHC26050 µgP78536RUO
AbbexaADAM17abx461559Disintegrin And Metalloproteinase Domain-Containing Protein 17 (ADAM17) AntibodyHumanMonoclonalCHO cellsDisintegrin And Metalloproteinase Domain-Containing Protein 17 (ADAM17)VHH-8His-Cys-tagUnconjugatedELISA442100 µgP78536RUO
AbbexaADAM17abx037459ADAM Metallopeptidase Domain 17 (ADAM17) AntibodyHumanPolyclonalRabbitADAM Metallopeptidase Domain 17 (ADAM17)IgGUnconjugatedELISA, WB, IHC357.5100 µgRUO
AbbexaADAM17abx028423ADAM Metallopeptidase Domain 17 (ADAM17) AntibodyHumanPolyclonalRabbitADAM Metallopeptidase Domain 17 (ADAM17)IgGUnconjugatedELISA, WB, FCM292.580 µlP78536RUO
AbbexaADAM17abx323786A Disintegrin And Metalloprotease 17 Cleaved-Arg215 (ADAM17 Cleaved-R215) AntibodyHumanPolyclonalRabbitA Disintegrin And Metalloprotease 17 Cleaved-Arg215 (ADAM17 Cleaved-R215)IgGUnconjugatedELISA, WB22150 µgP78536RUO
AbbexaADAM17abx270907A Disintegrin And Metalloprotease 17 (ADAM17) Antibody (PE)HumanMonoclonalMouseA Disintegrin And Metalloprotease 17 (ADAM17)IgGPEFCM585100 testsRUO
AbbexaADAM17abx270675A Disintegrin And Metalloprotease 17 (ADAM17) Antibody (APC)HumanMonoclonalMouseA Disintegrin And Metalloprotease 17 (ADAM17)IgGAPCFCM689100 testsRUO
AbbexaADAM17abx131773A Disintegrin And Metalloprotease 17 (ADAM17) AntibodyHumanMonoclonalMouseA Disintegrin And Metalloprotease 17 (ADAM17)IgG1 KappaUnconjugatedWB, IHC, IF/ICC247100 µlP78536RUO
AbbexaADAM17abx028424ADAM Metallopeptidase Domain 17 (ADAM17) AntibodyHumanPolyclonalRabbitADAM Metallopeptidase Domain 17 (ADAM17)IgGUnconjugatedELISA, WB292.580 µlP78536RUO
AbbexaADAM17abx273695A Disintegrin And Metalloprotease 17 (ADAM17) Antibody (FITC)HumanPolyclonalRabbitA Disintegrin And Metalloprotease 17 (ADAM17)IgGFITCWB, IHC, IF/ICC364200 µlRUO
AbbexaADAM17abx230139ADAM17-Specific AntibodyHumanPolyclonalRabbitADAM17-SpecificIgGUnconjugatedELISA, WB364100 µgP78536RUO
AbbexaADAM17abx015548A Disintegrin And Metalloprotease 17 Cleaved-Arg215 (ADAM17 Cleaved-R215) AntibodyHumanPolyclonalRabbitA Disintegrin And Metalloprotease 17 Cleaved-Arg215 (ADAM17 Cleaved-R215)IgGUnconjugatedELISA, WB5210 µgP78536RUO
AbbexaADAM17abx430638ADAM Metallopeptidase Domain 17 (ADAM17) AntibodyHumanPolyclonalGoatADAM Metallopeptidase Domain 17 (ADAM17)IgGUnconjugatedP-ELISA, WB416200 µlRUO
AbbexaADAM17abx421535Disintegrin And Metalloproteinase Domain-Containing Protein 17 (ADAM17) AntibodyHumanMonoclonalRatDisintegrin And Metalloproteinase Domain-Containing Protein 17 (ADAM17)IgG1 KappaUnconjugatedELISA, FCM31250 µgQ9Z0F8RUO
AbbexaADAM17abx110819A Disintegrin And Metalloprotease 17 (ADAM17) AntibodyHumanPolyclonalRabbitA Disintegrin And Metalloprotease 17 (ADAM17)IgGUnconjugatedELISA, WB637100 µlP78536RUO
AbbexaADAM17abx213698A Disintegrin And Metalloprotease 17 (ADAM17) AntibodyHumanPolyclonalRabbitA Disintegrin And Metalloprotease 17 (ADAM17)IgGUnconjugatedELISA, IHC26050 µlP78536RUO
AbbexaADAM17abx230138ADAM Metallopeptidase Domain 17 (ADAM17) AntibodyHumanPolyclonalRabbitADAM Metallopeptidase Domain 17 (ADAM17)IgGUnconjugatedELISA, WB, IHC364100 µgP78536RUO
AbbexaADAM17abx328562A Disintegrin And Metalloprotease 17 Phospho-Thr735 (ADAM17 pT735) AntibodyHumanPolyclonalRabbitA Disintegrin And Metalloprotease 17 Phospho-Thr735 (ADAM17 pT735)IgGUnconjugatedELISA, WB, IHC22150 µgP78536RUO
AbbexaADAM17abx000869ADAM Metallopeptidase Domain 17 (ADAM17) AntibodyHumanPolyclonalRabbitADAM Metallopeptidase Domain 17 (ADAM17)IgGUnconjugatedIHC31260 µlP78536RUO
AbbexaADAM17abx326388A Disintegrin And Metalloprotease 17 (ADAM17) AntibodyHumanPolyclonalRabbitA Disintegrin And Metalloprotease 17 (ADAM17)IgGUnconjugatedELISA, IF/ICC22150 µgP78536RUO
AbbexaADAM17abx171029A Disintegrin And Metalloprotease 17 (ADAM17) AntibodyRatMonoclonalMouseA Disintegrin And Metalloprotease 17 (ADAM17)UnconjugatedWB, IHC, IF/ICC8451 mlRUO
AbbexaADAM17abx130120A Disintegrin And Metalloprotease 17 (ADAM17) AntibodyRatPolyclonalRabbitA Disintegrin And Metalloprotease 17 (ADAM17)UnconjugatedWB, IHC, IF/ICC286100 µlQ9Z1K9RUO

Proteins and Peptides

providerCodereferencenameoriginexpressionhostconjugationtested applicationspricesize 1uniprot idstatus
AbbexaADAM17abx167725Rat A Disintegrin And Metalloprotease 17 (ADAM17) ProteinRatRecombinantE. coliUnconjugatedWB, SDS-PAGE23410 µgRUO
AbbexaADAM17abx065059Human A Disintegrin And Metalloprotease 17 (ADAM17) ProteinHumanRecombinantE. coliUnconjugatedWB, SDS-PAGE22110 µgP78536RUO
AbbexaADAM17abx269139ADAM Metallopeptidase Domain 17 (ADAM17) PeptideSyntheticUnconjugatedP-ELISA175.5100 µg
AbbexaADAM17abx266764TACE (ADAM-17) PeptideUnconjugated2211 mgRUO
FineTestADAM17P0557Recombinant Human ADAM17HumanRecombinantE.ColiWestern Blot, ELISA50μgP78536RUO

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