Disintegrin And Metalloproteinase Domain-Containing Protein 17 (ADAM17) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Disintegrin And Metalloproteinase Domain-Containing Protein 17 (ADAM17) Antibody is a Rabbit polyclonal antibody for the detection of Human Disintegrin And Metalloproteinase Domain-Containing Protein 17 (ADAM17).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Disintegrin And Metalloproteinase Domain-Containing Protein 17 (ADAM17) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P78536 |
| Gene ID | 6868 |
| NCBI Accession | NP_003174.3 |
| Alias | CSVP, CD156B, TACE,TNF-Alpha Convertase,TNF-Alpha Converting enzyme,adam-17 |
| Background | Antibody anti-ADAM17 |
| Status | RUO |
Descripción
Related Products
Human ADAM17(Disintegrin and metalloproteinase domain-containing protein 17) ELISA Kit
Ver Producto
Mouse adam17 (Disintegrin and metalloproteinase domain-containing protein 17) ELISA Kit
Ver Producto
anti- ADAM17 antibody
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease.
Ver Producto