Zinc Finger MIZ-Type Containing 1 (ZMIZ1) Antibody
260€ (50 µl)
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935106861
info@markelab.com
name
Zinc Finger MIZ-Type Containing 1 (ZMIZ1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx211879
tested applications
ELISA, WB, IHC
Description
ZMIZ1 Antibody is a Rabbit Polyclonal against ZMIZ1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Zinc Finger MIZ-Type Containing 1 (ZMIZ1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/1000 - 1/2000, WB: 1/200 - 1/1000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9ULJ6 |
| Gene ID | 57178 |
| Alias | MIZ,NEDDFSA,RAI17,TRAFIP10,ZIMP10,PIAS-like protein Zimp10,Retinoic acid-induced protein 17 |
| Background | Antibody anti-ZMIZ1 |
| Status | RUO |
Descripción
Zinc Finger MIZ-Type Containing 1 (ZMIZ1) is a transcriptional co-activator and a member of the PIAS-like (protein inhibitor of activated STAT) family which regulates transcription by interacting with transcription factors and chromatin-modifying proteins ZMIZ1 contains a MIZ domain that mediates protein-protein interactions and is involved in enhancing the activity of androgen receptors (AR) SMAD proteins and p53 signaling pathways It contributes to cell proliferation and differentiation particularly in immune cells and hematopoietic stem cells Aberrant expression or mutations in ZMIZ1 have been associated with cancers such as leukemia and breast cancer due to its role in activating oncogenic pathways ZMIZ1 is also implicated in autoimmune diseases such as systemic lupus erythematosus and multiple sclerosis where it influences T-cell activation and immune tolerance highlighting its role in transcriptional regulation and immune homeostasis
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