Zinc finger MIZ domain-containing protein 1 (ZMIZ1) Antibody (Biotin)
169€ (20 µg)
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935106861
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name
Zinc finger MIZ domain-containing protein 1 (ZMIZ1) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx349528
tested applications
ELISA
Description
Zinc finger MIZ domain-containing protein 1 (ZMIZ1) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin for the detection of Human ZMIZ1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Zinc finger MIZ domain-containing protein 1 (ZMIZ1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G chromatography. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9ULJ6 |
| Alias | MIZ,NEDDFSA,RAI17,TRAFIP10,ZIMP10,PIAS-like protein Zimp10,Retinoic acid-induced protein 17 |
| Background | Antibody anti-ZMIZ1 |
| Status | RUO |
Descripción
Zinc Finger MIZ-Type Containing 1 (ZMIZ1) is a transcriptional co-activator and a member of the PIAS-like (protein inhibitor of activated STAT) family which regulates transcription by interacting with transcription factors and chromatin-modifying proteins ZMIZ1 contains a MIZ domain that mediates protein-protein interactions and is involved in enhancing the activity of androgen receptors (AR) SMAD proteins and p53 signaling pathways It contributes to cell proliferation and differentiation particularly in immune cells and hematopoietic stem cells Aberrant expression or mutations in ZMIZ1 have been associated with cancers such as leukemia and breast cancer due to its role in activating oncogenic pathways ZMIZ1 is also implicated in autoimmune diseases such as systemic lupus erythematosus and multiple sclerosis where it influences T-cell activation and immune tolerance highlighting its role in transcriptional regulation and immune homeostasis
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