Zinc Finger CCCH-Type Antiviral Protein 1 (ZC3HAV1) Antibody

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Description
Zinc Finger CCCH-Type Antiviral Protein 1 (ZC3HAV1) Antibody is a Rabbit polyclonal antibody for the detection of Human Zinc Finger CCCH-Type Antiviral Protein 1 (ZC3HAV1).
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Product specifications
Category | Primary Antibodies |
Immunogen Target | Zinc Finger CCCH-Type Antiviral Protein 1 (ZC3HAV1) |
Host | Rabbit |
Reactivity | Human |
Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Isotype | IgG |
Size 1 | 50 µg |
Size 2 | 100 µg |
Form | Liquid |
Tested Applications | ELISA, WB, IHC |
Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
Availability | Shipped within 5-12 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | Q7Z2W4 |
Gene ID | 56829 |
NCBI Accession | NP_064504.2 |
Background | Antibody anti-ZC3HAV1 |
Status | RUO |
Descripción
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ZC3HAV1 antibody
Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element(ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72(DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1(HIV-1), moloney and murine leukemia virus(MoMLV) and xenotropic MuLV-related virus(XMRV), filoviridae: ebola virus(EBOV) and marburg virus(MARV), togaviridae: sindbis virus(SINV) and Ross river virus(RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes(ISGs).
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Zinc Finger CCCH-Type Antiviral Protein 1 (ZC3HAV1) Antibody
ZC3HAV1 Antibody is a Rabbit Polyclonal Antibody against ZC3HAV1.
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