ZC3HAV1 antibody

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935106861
info@markelab.com
name
ZC3HAV1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab09606
tested applications
ELISA, WB, IHC

Description

Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element(ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72(DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1(HIV-1), moloney and murine leukemia virus(MoMLV) and xenotropic MuLV-related virus(XMRV), filoviridae: ebola virus(EBOV) and marburg virus(MARV), togaviridae: sindbis virus(SINV) and Ross river virus(RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes(ISGs).

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
zinc finger CCCH-type, antiviral 1 (ZC3HAV1)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:1000-1:10000; IHC: 1:20-1:200; IP: 1:1000-1:4000
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
101 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, IHC
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
Q7Z2W4
Gene ID
56829
Alias
Zinc finger CCCH-type antiviral protein 1,ADP-ribosyltransferase diphtheria toxin-like 13 (ARTD13),Inactive Poly [ADP-ribose] polymerase 13 (PARP13),Zinc finger CCCH domain-containing protein 2,Zinc finger antiviral protein (ZAP),ZC3HAV1,ZC3HDC2
Background
Antibody anti-ZC3HAV1
Status
RUO
Note
Mol. Weight 101 kDa

Descripción

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ZC3HAV1 antibody

Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element(ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72(DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1(HIV-1), moloney and murine leukemia virus(MoMLV) and xenotropic MuLV-related virus(XMRV), filoviridae: ebola virus(EBOV) and marburg virus(MARV), togaviridae: sindbis virus(SINV) and Ross river virus(RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes(ISGs).

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