WD Repeat And FYVE Domain-Containing Protein 4 (WDFY4) Antibody
195€ (20 µl)
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Name
WD Repeat And FYVE Domain-Containing Protein 4 (WDFY4) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx003720
Tested Applications
ELISA, WB
Description
WDFY4 Antibody is a Rabbit Polyclonal antibody against WDFY4.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: WD Repeat And FYVE Domain-Containing Protein 4 (WDFY4) Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human WDFY4. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 354 kDa Observed MW: 354 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6ZS81 |
| Gene ID | 57705 |
| NCBI Accession | NP_065996.1 |
| Alias | C10orf64,KIAA1607,WDFY family member 4 |
| Background | Antibody anti-WDFY4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
WD repeat and FYVE domain containing 4 (WDFY4), like WDFY3, is a protein that features WD repeats and a FYVE domain, which suggest its role in protein-protein interactions and endosomal trafficking. The FYVE domain in WDFY4 specifically binds phosphoinositides, a type of lipid critical for the regulation of vesicle trafficking and cellular membrane dynamics. Through its interaction with these lipids, WDFY4 is involved in the sorting of proteins within the endosomal system and the regulation of receptor recycling. This function is essential for maintaining proper cellular signaling, receptor downregulation, and protein degradation. WDFY4 also plays a role in regulating autophagy, a process crucial for maintaining cellular homeostasis by degrading and recycling damaged or unnecessary components. Moreover, WDFY4's involvement in immune function has been noted, with potential implications in diseases affecting immune responses and inflammatory processes. Given its critical role in vesicular trafficking and autophagy, disruptions in WDFY4's function could lead to disorders such as neurodegenerative diseases and autoimmune conditions. Understanding the full scope of WDFY4's role in cellular trafficking and immune regulation is essential for identifying novel therapeutic targets in related diseases.
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