WD Repeat And FYVE Domain-Containing Protein 3 (WDFY3) Antibody (ATTO594)

Background

WD repeat and FYVE domain containing 3 (WDFY3) is a protein that contains WD repeats and a FYVE domain, both of which are known for their roles in protein interactions and intracellular signaling. The WD repeats are typically involved in mediating interactions with other proteins, often forming large complexes that regulate various cellular processes. The FYVE domain in WDFY3 allows it to bind to phosphoinositides, specifically to the lipid molecules found in the membrane of endosomes and other intracellular vesicles. This interaction is crucial for the protein's role in vesicular trafficking and membrane dynamics, where it is involved in sorting and regulating endocytic cargo. Additionally, WDFY3 has been implicated in cellular processes such as autophagy and immune responses, both of which are essential for maintaining cellular homeostasis and immunity. Dysregulation of WDFY3 has been associated with several disorders, particularly those affecting cellular transport and immune function. Understanding how WDFY3 functions within the endosomal network and its role in various signaling pathways is critical for the development of therapeutic strategies aimed at diseases involving vesicular trafficking and immune dysregulation.