WDFY3 antibody
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Description
Required for selective autophagy(aggrephagy) but not for autophagic degradation of bulk cytospol in response to starvation. Involved in the formation and degradation of cytoplasmic polyubiquitin-containing bodies(p62 bodies, ALIS/aggresome-like induced structures). May play a role as adaptor or scaffolding protein by promoting the association of the E3-like ligase ATG12-ATG5-ATG16L and LC3 to ubiquitinated target substrate. The association with GABARAP is required for its recruitment to LC3B-positive p62 bodies suggesting a role in targeting certain p62 structures for clearance. Involved in midbody ring degradation.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | WD repeat and FYVE domain containing 3 (WDFY3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8IZQ1 |
| Gene ID | 23001 |
| Alias | ALFY,BCHS,MCPH18,ZFYVE25,KIAA0993,Autophagy-linked FYVE protein (Alfy) |
| Background | Antibody anti-WDFY3 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
WD repeat and FYVE domain containing 3 (WDFY3) is a protein that contains WD repeats and a FYVE domain, both of which are known for their roles in protein interactions and intracellular signaling. The WD repeats are typically involved in mediating interactions with other proteins, often forming large complexes that regulate various cellular processes. The FYVE domain in WDFY3 allows it to bind to phosphoinositides, specifically to the lipid molecules found in the membrane of endosomes and other intracellular vesicles. This interaction is crucial for the protein's role in vesicular trafficking and membrane dynamics, where it is involved in sorting and regulating endocytic cargo. Additionally, WDFY3 has been implicated in cellular processes such as autophagy and immune responses, both of which are essential for maintaining cellular homeostasis and immunity. Dysregulation of WDFY3 has been associated with several disorders, particularly those affecting cellular transport and immune function. Understanding how WDFY3 functions within the endosomal network and its role in various signaling pathways is critical for the development of therapeutic strategies aimed at diseases involving vesicular trafficking and immune dysregulation.
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