WD Repeat And FYVE Domain-Containing Protein 2 (WDFY2) Antibody

Background

WD repeat and FYVE domain containing 2 (WDFY2) shares similarities with WDFY1, as it also contains WD repeats and a FYVE domain that enable it to participate in cellular signaling and membrane trafficking. This protein is involved in processes like receptor endocytosis and lysosomal degradation, where it interacts with other proteins to regulate the movement of vesicles within the cell. Like WDFY1, WDFY2 binds phosphoinositides, which are key molecules in cellular membrane dynamics. The role of WDFY2 in vesicular sorting makes it crucial for the regulation of the recycling of various membrane receptors, thus ensuring proper cell signaling and receptor function. WDFY2 also plays a role in immune responses, influencing processes like antigen presentation and immune cell activation. Studies suggest that WDFY2's function is essential for maintaining immune homeostasis, and its dysregulation has been linked to autoimmune disorders and immune deficiencies. As a result, understanding how WDFY2 interacts with other cellular machinery is important for developing therapeutic strategies targeting vesicular trafficking in diseases related to immune dysfunction.