WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1 (WFIKKN1) Antibody
169€ (20 µl)
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935106861
info@markelab.com
name
WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1 (WFIKKN1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx348302
tested applications
ELISA, IHC
Description
WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1 (WFIKKN1) Antibody is a Rabbit Polyclonal antibody for the detection of Human WFIKKN1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1 (WFIKKN1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96NZ8 |
| Alias | RJD2,WFIKKNL,WFDC20A,C16orf12,Growth and differentiation factor-associated serum protein 2,GASP-2,hGASP-2 |
| Background | Antibody anti-WFIKKN1 |
| Status | RUO |
Descripción
WAP follistatin/kazal immunoglobulin kunitz and netrin domain containing 1 (WFIKKN1) is a secreted multidomain protease inhibitor that plays a key role in regulating extracellular proteolytic activity. This protein contains multiple functional domains, including WAP (whey acidic protein), follistatin, kazal, immunoglobulin, kunitz, and netrin-like domains, which collectively enable it to bind and inhibit a wide range of proteases such as trypsin, chymotrypsin, and matrix metalloproteinases. WFIKKN1 is highly expressed in musculoskeletal tissues and acts as a regulator of tissue remodeling, particularly in processes involving myostatin, a negative regulator of muscle growth. By inhibiting myostatin, WFIKKN1 contributes to muscle development and repair. It is also involved in wound healing, fibrosis, and cancer progression, where protease regulation is critical. Dysregulation of WFIKKN1 expression is associated with pathological conditions such as fibrosis, where excessive extracellular matrix deposition occurs, and certain cancers, where it may modulate tumor invasion and metastasis. Ongoing research aims to explore its potential as a therapeutic target for enhancing muscle mass in muscular dystrophies and mitigating tissue damage in chronic inflammatory diseases.
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