Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
292.5€ (50 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx032864
Tested Applications
ELISA, WB, IHC, IF/ICC, FCM
Description
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of VHL gene is the basis of familial inheritance of VHL syndrome. The protein is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Von Hippel-Lindau Disease Tumor Suppressor (VHL) Immunogen: KLH-conjugated synthetic peptide between 43-71 amino acids from the N-terminal region of human VHL. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/2000, IHC-P: 1/25, IF/ICC: 1/25, FCM: 1/25. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 24.2 kDa |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Size 1 | 50 µl |
| Size 2 | 200 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P40337 |
| NCBI Accession | NP_000542.1, NP_937799.1 |
| Background | Antibody anti-VHL |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Productos relacionados
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
VHL Antibody is a Rabbit Polyclonal antibody against VHL. The Von Hippel-Lindau (VHL) protein is a substrate recognition…
Ver producto
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody is a Rabbit Polyclonal antibody for the detection of VHL.…
Ver producto Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of maligna…
Ver producto