Voltage-Gated Potassium Channel Subunit Beta-2 (KCNAB2) Antibody
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Description
Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Beta Member 2 Antibody is a Rabbit Polyclonal antibody against Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Beta Member 2.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Voltage-Gated Potassium Channel Subunit Beta-2 (KCNAB2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13303 |
| Gene ID | 8514 |
| NCBI Accession | NP_001186789.1, NM_001199860.1 |
| OMIM | 601142 |
| Background | Antibody anti-KCNAB2 |
| Status | RUO |
Descripción
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Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits(PubMed:7649300, PubMed:11825900). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability(By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity(By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore(PubMed:7649300, PubMed:11825900). Promotes KCNA4 channel closure(PubMed:7649300, PubMed:11825900). Modulates the functional properties of KCNA5(By similarity). Enhances KCNB2 channel activity(By similarity). Binds NADPH and has NADPH-dependent aldoketoreductase activity(By similarity). Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal(in vitro)(By similarity).
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