Vascular Endothelial Growth Factor C (VEGFC) Antibody
292.5€ (50 µl)
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935106861
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name
Vascular Endothelial Growth Factor C (VEGFC) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx025249
tested applications
ELISA, WB
Description
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D. [provided by RefSeq].
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Vascular Endothelial Growth Factor C (VEGFC) |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 Kappa |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Size 1 | 50 µl |
| Size 2 | 200 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P49767 |
| Alias | VRP,Flt4-L,LMPH1D,LMPHM4,Vascular endothelial growth factor-related protein |
| Background | Antibody anti-VEGFC |
| Status | RUO |
Descripción
VEGFC is primarily responsible for lymphangiogenesis, the formation of lymphatic vessels, by binding to VEGFR-3 on lymphatic endothelial cells During embryonic development and tissue repair, VEGFC promotes the sprouting and maturation of lymphatic vessels VEGFC also activates VEGFR-2 in certain contexts, contributing to angiogenesis and vascular remodeling VEGFC plays a significant role in pathological processes, including cancer metastasis, where it enhances lymphatic vessel growth and facilitates tumor cell dissemination via the lymphatic system Overexpression of VEGFC is observed in various cancers such as breast cancer, melanoma, and prostate cancer, correlating with lymph node metastasis Targeting VEGFC signaling is a promising strategy to inhibit lymphangiogenesis and reduce cancer spread while maintaining tissue fluid balance and immune cell trafficking
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