Vascular Endothelial Cell Growth Factor (VEGF) Antibody
234€ (1 mg)
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Name
Vascular Endothelial Cell Growth Factor (VEGF) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx137725
Tested Applications
SDS-PAGE
Description
Vascular Endothelial Cell Growth Factor (VEGF) Antibody is a CHO Cells Monoclonal antibody against Vascular Endothelial Cell Growth Factor (VEGF).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Vascular Endothelial Cell Growth Factor (VEGF) |
| Host | CHO cells |
| Clonality | Monoclonal |
| Expression | Recombinant |
| Purity | > 95% (SEC-HPLC and SDS-PAGE) |
| Size 1 | 1 mg |
| Size 2 | 10 mg |
| Size 3 | 100 mg |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| Alias | L-VEGF,MVCD1,VEGF,VPF,Vascular permeability factor |
| Background | Antibody anti-VEGFA |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
VEGFA is a key member of the vascular endothelial growth factor (VEGF) family and plays a crucial role in angiogenesis, vascular permeability, and endothelial cell proliferation VEGFA binds primarily to its receptors VEGFR-1 and VEGFR-2, triggering signaling pathways like PI3K/AKT and ERK/MAPK to promote blood vessel formation during embryonic development, wound healing, and tissue repair Dysregulated VEGFA expression is associated with pathological angiogenesis observed in cancer, diabetic retinopathy, and age-related macular degeneration (AMD) VEGFA also increases vascular permeability by altering endothelial junctions, contributing to fluid leakage in conditions such as inflammation and tumors Targeted therapies, such as bevacizumab and other anti-VEGF agents, inhibit VEGFA activity to suppress angiogenesis and tumor growth in various cancers and ocular diseases
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