Vascular Cell Adhesion Molecule 1 (VCAM1) Antibody (PE)

Product specifications

Primary Antibodies

Vascular Cell Adhesion Molecule 1 (VCAM1)

Rat

Mouse

Optimal dilutions/concentrations should be determined by the end user.

Monoclonal

PE

IgG2a Kappa

R174

The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.

0.1 mg

FCM

PBS solution with 15 mM sodium azide.

Shipped within 5-12 working days.

Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze.

No

Q3UPN1

22329

V-CAM 1,VCAM-1,INCAM-100,CD106

Antibody anti-VCAM1

RUO

Concentration: 0.5 mg/ml - 

Descripción

VCAM1 is a transmembrane glycoprotein and member of the immunoglobulin superfamily that plays a key role in cell adhesion, particularly in leukocyte-endothelial interactions during inflammation VCAM1 is expressed on endothelial cells in response to pro-inflammatory cytokines such as TNF-α and IL-1β where it mediates the adhesion and transmigration of leukocytes, including monocytes and lymphocytes, into inflamed tissues VCAM1 interacts with its ligand VLA-4 (integrin α4β1) to facilitate immune cell recruitment during acute and chronic inflammatory responses VCAM1 is implicated in various diseases including atherosclerosis, where it promotes monocyte adhesion to endothelial cells and contributes to plaque formation Elevated VCAM1 levels are also associated with rheumatoid arthritis, multiple sclerosis, and other autoimmune disorders, where persistent inflammation leads to tissue damage VCAM1 serves as a biomarker for endothelial activation and vascular inflammation, making it a potential target for therapeutic interventions aimed at reducing leukocyte recruitment and chronic inflammation

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