V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (Lyn) Antibody
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Description
Lyn Antibody is a Mouse Monoclonal against Lyn.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (Lyn) |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | H121 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | WB, IF/ICC, IP |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P07948 |
| Gene ID | 4067 |
| Background | Antibody anti-Lyn |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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Mouse Lyn Antibody
Lyn acts as a positive regulator of cell movement while negatively regulating adhesion to stromal cells by inhibiting the ICAM-1-binding activity of beta-2 integrins. Acts as the mediator that relays suppressing signals from the chemokine receptor CXCR4 to beta-2 integrin LFA-1 in hematopoietic precursors. Involved in induction of stress-activated protein kinase (SAPK), but not ERK or p38 MAPK, in response to genotoxic agents. Induces SAPK by a MKK7-and MEKK1-dependent mechanism. The LYN > MEKK1 > MKK7 > SAPK pathway is functional in the induction of apoptosis by genotoxic agents (By similarity). Down regulates expression of stem cell growth factor receptor (KIT). Acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between proliferation and maturation.
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V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (Lyn) Antibody
Lyn Antibody is a Mouse Monoclonal against Lyn.
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