UV Radiation Resistance-Associated Gene Protein (UVRAG) Antibody

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Description
UVRAG Antibody is a Rabbit Polyclonal Antibody against UVRAG.
Documents del producto
Product specifications
Category | Primary Antibodies |
Immunogen Target | UV Radiation Resistance-Associated Gene Protein (UVRAG) |
Host | Rabbit |
Reactivity | Human, Mouse, Rat |
Recommended Dilution | IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Isotype | IgG |
Purification | Purified by affinity chromatography. |
Size 1 | 60 µl |
Size 2 | 120 µl |
Size 3 | 200 µl |
Form | Liquid |
Tested Applications | IHC |
Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
Availability | Shipped within 5-10 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | Q9P2Y5 |
Gene ID | 7405 |
NCBI Accession | NP_003360.2 |
Background | Antibody anti-UVRAG |
Status | RUO |
Note | Concentration: 1 mg/ml - |
Descripción
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This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.
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UV Radiation Resistance-Associated Gene Protein (UVRAG) Antibody
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UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI (3) KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.
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