Urotensin 2 Receptor (UTS2R) Antibody
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Description
UTS2R Antibody is a Rabbit Polyclonal antibody against UTS2R. This gene codes high affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Urotensin 2 Receptor (UTS2R) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UKP6 |
| Gene ID | 2837 |
| NCBI Accession | NP_061822.1 |
| Alias | UTS2R,GPR14,UII-R1,UTR2,G protein-coupled receptor 14,urotensin II receptor,SENR,UR-2-R,UTR |
| Background | Antibody anti-UTS2R |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
UTS2R is a G protein-coupled receptor activated by urotensin 2 (U-2), a potent vasoconstrictor peptide involved in regulating cardiovascular function, particularly blood pressure and vascular tone. UTS2R couples to Gq proteins, activating phospholipase C (PLC) and increasing intracellular calcium levels, leading to vasoconstriction and modulation of smooth muscle contraction. Urotensin 2 is a critical mediator in the regulation of blood vessel function, and UTS2R’s expression in the vasculature suggests that it plays an important role in blood pressure homeostasis and vascular remodeling. Dysregulation of UTS2R signaling is associated with cardiovascular diseases such as hypertension and heart failure. Antagonists of UTS2R are being explored for their therapeutic potential in treating conditions related to excessive vasoconstriction, including pulmonary arterial hypertension and atherosclerosis.
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