Urokinase Plasminogen Activator Surface Receptor / uPAR / CD87 (PLAUR) Antibody (PE)
429€ (100 tests)
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Name
Urokinase Plasminogen Activator Surface Receptor / uPAR / CD87 (PLAUR) Antibody (PE)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx140375
Tested Applications
FCM
Description
CD87 Antibody is a Mouse Monoclonal against CD87.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Urokinase Plasminogen Activator Surface Receptor / uPAR / CD87 (PLAUR) Immunogen: Human myeloid cell line THP-1. |
| Host | Mouse |
| Reactivity | Human |
| Detection Method | Laser Line: 550 Excitation/Emission: 565/575 |
| Recommended Dilution | FCM: 10 µl/100 µl of whole blood or 106 cells. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | PE |
| Isotype | IgG1 |
| Clone ID | X517 |
| Size 1 | 100 tests |
| Tested Applications | FCM |
| Buffer | Stabilizing PBS solution containing 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | Q03405 |
| Gene ID | 5329 |
| Alias | CD87,UPAR,URKR,U-PAR,Urokinase plasminogen activator surface receptor,Monocyte activation antigen Mo3 |
| Background | Antibody anti-PLAUR |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
The plasminogen activator, urokinase receptor (PLAUR), also known as urokinase plasminogen activator receptor (uPAR), is a cell surface receptor that plays a pivotal role in modulating extracellular matrix degradation, cell adhesion, and migration. PLAUR is mainly expressed on various cell types, including immune cells (like monocytes and neutrophils), endothelial cells, and cancer cells, and it orchestrates processes crucial for tissue remodeling, inflammation, and metastasis. PLAUR facilitates these processes by binding to urokinase-type plasminogen activator (uPA) and concentrating proteolytic activity on the cell surface, contributing to localized extracellular proteolysis and influencing signal transduction pathways that mediate cell movement and adhesion. This receptor is encoded by the PLAUR gene, located on chromosome 19q13, and belongs to the Ly6/uPAR/α-neurotoxin receptor family, a superfamily of proteins involved in signal transduction.
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