Urokinase plasminogen activator surface receptor (PLAUR) Antibody
299€ (50 µl)
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Name
Urokinase plasminogen activator surface receptor (PLAUR) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx349948
Tested Applications
ELISA, IF/ICC, FCM
Description
Urokinase plasminogen activator surface receptor (PLAUR) Antibody is a Recombinant Mouse Monoclonal antibody for the detection of Human PLAUR.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Urokinase plasminogen activator surface receptor (PLAUR) Immunogen: Recombinant Human PLAUR protein |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | IF/ICC: 1/20 - 1/200, FCM: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Expression | Recombinant |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC, FCM |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q03405 |
| Gene ID | 5329 |
| OMIM | 173391 |
| Alias | CD87,UPAR,URKR,U-PAR,Urokinase plasminogen activator surface receptor,Monocyte activation antigen Mo3 |
| Background | Antibody anti-PLAUR |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
The plasminogen activator, urokinase receptor (PLAUR), also known as urokinase plasminogen activator receptor (uPAR), is a cell surface receptor that plays a pivotal role in modulating extracellular matrix degradation, cell adhesion, and migration. PLAUR is mainly expressed on various cell types, including immune cells (like monocytes and neutrophils), endothelial cells, and cancer cells, and it orchestrates processes crucial for tissue remodeling, inflammation, and metastasis. PLAUR facilitates these processes by binding to urokinase-type plasminogen activator (uPA) and concentrating proteolytic activity on the cell surface, contributing to localized extracellular proteolysis and influencing signal transduction pathways that mediate cell movement and adhesion. This receptor is encoded by the PLAUR gene, located on chromosome 19q13, and belongs to the Ly6/uPAR/α-neurotoxin receptor family, a superfamily of proteins involved in signal transduction.
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