UBXN8 Antibody (FITC)
169€ (20 µg)
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935106861
info@markelab.com
name
UBXN8 Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx305878
Description
UBXN8 Antibody (FITC) is a Rabbit Polyclonal against UBXN8 conjugated to FITC.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | UBXN8 |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O00124 |
| Gene ID | 7993 |
| NCBI Accession | NP_001269118.1, NM_001282189.1, NP_001269128.1, NM_001282199.1, NP_005662.1, NM_005671.3 |
| OMIM | 602155 |
| Alias | D8S2298E,REP8,UBXD6,Reproduction 8 protein,UBX domain-containing protein 6 |
| Background | Antibody anti-UBXN8 |
| Status | RUO |
Descripción
UBX domain protein 8 (UBXN8) is a member of the UBX domain-containing protein family that functions as a critical cofactor of p97/VCP, an ATPase involved in protein degradation and cellular quality control UBXN8 plays a role in the extraction and degradation of ubiquitinated proteins, particularly through endoplasmic reticulum-associated degradation (ERAD) and proteasomal pathways It participates in maintaining proteostasis under stress conditions by linking p97 to the ubiquitin-proteasome system and autophagy pathways UBXN8 also regulates mitochondrial homeostasis, ensuring the turnover of damaged proteins and contributing to cellular energy metabolism Dysregulation of UBXN8 has been associated with neurodegenerative diseases such as Parkinson’s, where protein clearance pathways are impaired, leading to toxic protein aggregates Emerging studies suggest that UBXN8 also influences DNA repair processes and cellular responses to oxidative stress In cancer biology, altered UBXN8 expression has been linked to tumor progression and resistance to therapy through its role in protein turnover and apoptosis regulation Its critical functions in proteostasis, mitochondrial health, and cellular stress responses underscore its importance in maintaining cellular homeostasis
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