UBX Domain-Containing Protein 8 (UBXN8) Antibody

Este producto es parte de UBXN - UBX domain protein
Product Graph
292.5€ (80 µl)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
UBX Domain-Containing Protein 8 (UBXN8) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx029031
tested applications
ELISA, WB

Description

UBXN8 may play a role in reproduction.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
UBX Domain-Containing Protein 8 (UBXN8)
Host
Rabbit
Reactivity
Human
Recommended Dilution
WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified through a protein A column, followed by peptide affinity purification.
Size 1
80 µl
Size 2
400 µl
Form
Liquid
Tested Applications
ELISA, WB
Buffer
PBS containing 0.09% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
O00124
Alias
D8S2298E,REP8,UBXD6,Reproduction 8 protein,UBX domain-containing protein 6
Background
Antibody anti-UBXN8
Status
RUO

Descripción

UBX domain protein 8 (UBXN8) is a member of the UBX domain-containing protein family that functions as a critical cofactor of p97/VCP, an ATPase involved in protein degradation and cellular quality control UBXN8 plays a role in the extraction and degradation of ubiquitinated proteins, particularly through endoplasmic reticulum-associated degradation (ERAD) and proteasomal pathways It participates in maintaining proteostasis under stress conditions by linking p97 to the ubiquitin-proteasome system and autophagy pathways UBXN8 also regulates mitochondrial homeostasis, ensuring the turnover of damaged proteins and contributing to cellular energy metabolism Dysregulation of UBXN8 has been associated with neurodegenerative diseases such as Parkinson’s, where protein clearance pathways are impaired, leading to toxic protein aggregates Emerging studies suggest that UBXN8 also influences DNA repair processes and cellular responses to oxidative stress In cancer biology, altered UBXN8 expression has been linked to tumor progression and resistance to therapy through its role in protein turnover and apoptosis regulation Its critical functions in proteostasis, mitochondrial health, and cellular stress responses underscore its importance in maintaining cellular homeostasis

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