UBX Domain Protein 2A (UBXN2A) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
UBX Domain Protein 2A (UBXN2A) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx026227
tested applications
ELISA, WB, IHC, FCM
Description
UBXN2A Antibody is a Rabbit Polyclonal antibody against UBXN2A.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | UBX Domain Protein 2A (UBXN2A) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P68543 |
| Alias | UBXD4,UBX domain-containing protein 4 |
| Background | Antibody anti-UBXN2A |
| Status | RUO |
Descripción
UBX domain protein 2A (UBXN2A) is a p97/VCP-interacting protein containing a UBX domain that regulates protein degradation pathways including endoplasmic reticulum-associated degradation (ERAD) and ubiquitin-proteasome systems UBXN2A acts as a cofactor for p97, facilitating the extraction and degradation of misfolded proteins and maintaining proteostasis under cellular stress conditions It also modulates autophagy by linking p97 to lysosomal pathways, ensuring the clearance of protein aggregates Dysregulation of UBXN2A expression has been linked to cancer progression, where its involvement in protein turnover supports tumor cell survival, metastasis, and resistance to therapy Emerging studies show that UBXN2A is critical for cellular stress responses, DNA repair, and apoptosis regulation in response to proteotoxic insults UBXN2A’s role in proteasome-mediated degradation and its influence on cellular homeostasis underscore its importance in neurodegeneration and cancer-related proteostasis dysfunction
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