UBX Domain-Containing Protein 2B (UBXN2B) Antibody

Este producto es parte de UBXN - UBX domain protein
Product Graph
357.5€ (100 µg)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
UBX Domain-Containing Protein 2B (UBXN2B) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx122006
tested applications
ELISA, WB, IHC

Description

Rabbit Polyclonal against the UBXN2B protein.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
UBX Domain-Containing Protein 2B (UBXN2B)
Host
Rabbit
Reactivity
Human
Recommended Dilution
ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by antigen affinity column chromatography.
Size 1
100 µg
Size 2
1 mg
Form
Lyophilized
Tested Applications
ELISA, WB, IHC
Buffer
Prior to lyophilization: 1% BSA and 0.02% NaN3.
Availability
Shipped within 7-15 working days.
Storage
Store at -20 °C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
NCBI Accession
BC113645
Alias
p37,NSFL1 cofactor p37,p97 cofactor p37
Background
Antibody anti-UBXN2B
Status
RUO
Note
Concentration: Lyophilized form: Not applicable.  After reconstitution: 1 mg/ml. -

Descripción

UBX domain protein 2B (UBXN2B) is a paralog of UBXN2A that also contains a UBX domain, enabling interaction with p97/VCP for the regulation of protein degradation pathways UBXN2B primarily participates in the extraction and clearance of misfolded proteins through endoplasmic reticulum-associated degradation (ERAD) and proteasomal pathways It plays a role in maintaining proteostasis, particularly under conditions of cellular stress, where protein turnover and quality control mechanisms are critical UBXN2B has been shown to influence apoptotic pathways by regulating p97-dependent protein degradation, ensuring appropriate cellular responses to stress Dysregulation of UBXN2B contributes to neurodegenerative diseases where defective protein clearance leads to protein aggregation and cellular toxicity Recent studies also indicate a role for UBXN2B in cancer biology, where it affects tumor cell survival and growth by modulating protein homeostasis and stress responses Its ability to regulate proteasome function highlights its importance in maintaining cellular integrity during proteotoxic stress and disease conditions

Related Products

P5807

Recombinant Human UBXN2B

Ver Producto
abx122006

UBX Domain-Containing Protein 2B (UBXN2B) Antibody

Rabbit Polyclonal against the UBXN2B protein.

Ver Producto
abx262633

UBX Domain Protein 2B Protein

UBXN2B is a recombinant protein.

Ver Producto