Ubiquitin-Related Modifier 1 (URM1) Antibody
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Description
Acts as a sulfur carrier required for 2-thiolation of mcm (5) S (2) U at tRNA wobble positions of tRNA (Lys), tRNA (Glu) and tRNA (Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm (5) S (2) U. May also act as an ubiquitin-like protein that is covalently conjugated to other proteins; the relevance of such function is however unclear in vivo.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Ubiquitin-Related Modifier 1 (URM1) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgM Kappa |
| Purification | Purified by Euglobin precipitation followed by dialysis against deionized water. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BTM9 |
| Background | Antibody anti-URM1 |
| Status | RUO |
Descripción
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Human URM1 (Ubiquitin-related modifier 1) ELISA Kit
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URM1 antibody
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated(-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein(UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
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Ubiquitin-Related Modifier 1 (URM1) Antibody
Acts as a sulfur carrier required for 2-thiolation of mcm (5) S (2) U at tRNA wobble positions of tRNA (Lys), tRNA (Glu) and tRNA (Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm (5) S (2) U. May also act as an ubiquitin-like protein that is covalently conjugated to other proteins; the relevance of such function is however unclear in vivo.
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