Ubiquitin-Like Protein ATG12 (ATG12) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998 [PubMed 9852036]).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Ubiquitin-Like Protein ATG12 (ATG12) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1/4000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2b Kappa |
| Purification | Purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O94817 |
| Gene ID | 9140 |
| OMIM | 609608 |
| Background | Antibody anti-ATG12 |
| Status | RUO |
Descripción
Related Products
Human ATG12 (Ubiquitin-like protein ATG12) ELISA Kit
Ver Producto
Rat ATG12 ( autophagy protein 12 ) ELISA Kit
Ver Producto
ATG12 antibody
Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.
Ver Producto