Ubiquitin-Conjugating Enzyme E2O (UBE2O) Antibody
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Description
Ubiquitin-Conjugating Enzyme E2O Antibody is a Rabbit Polyclonal antibody against Ubiquitin-Conjugating Enzyme E2O.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Ubiquitin-Conjugating Enzyme E2O (UBE2O) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9C0C9 |
| Gene ID | 63893 |
| Background | Antibody anti-UBE2O |
| Status | RUO |
Descripción
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UBE2O antibody
E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins(PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity(PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis(PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal(NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location(PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASH1, leading to promote endosomal F-actin assembly(PubMed:23452853).
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Ubiquitin-Conjugating Enzyme E2O (UBE2O) Antibody
Ubiquitin-Conjugating Enzyme E2O Antibody is a Rabbit Polyclonal antibody against Ubiquitin-Conjugating Enzyme E2O.
Ver Producto
Ubiquitin-Conjugating Enzyme E2 O (UBE2O) Antibody
UBE2O Antibody is a Rabbit Polyclonal against UBE2O.
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