Ubiquitin Carboxyl Terminal Hydrolase L5 (UCHL5) Antibody
312€ (60 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Ubiquitin Carboxyl Terminal Hydrolase L5 (UCHL5) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx007186
tested applications
IF/ICC
Description
UCHL5 Antibody is a Rabbit Polyclonal Antibody against UCHL5.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Ubiquitin Carboxyl Terminal Hydrolase L5 (UCHL5) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y5K5 |
| Gene ID | 51377 |
| NCBI Accession | NP_001186190.1 |
| Alias | UCH37,CGI-70,INO80R,UCH-L5,Ubiquitin carboxyl-terminal hydrolase isozyme L5,Ubiquitin thioesterase L5 |
| Background | Antibody anti-UCHL5 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
UCHL5, also known as UCH37, is a deubiquitinating enzyme (DUB) that plays a key role in the ubiquitin-proteasome system by removing ubiquitin chains from proteasomal substrates, thereby regulating protein turnover and degradation. UCHL5 interacts with the 19S regulatory particle of the 26S proteasome, facilitating the recycling of ubiquitin to maintain cellular proteostasis. It is involved in DNA repair, cell cycle progression, and stress responses, making it crucial for cellular homeostasis. UCHL5 has also been implicated in tumorigenesis, where its overexpression promotes cell survival, proliferation, and chemoresistance by preventing the degradation of oncogenic proteins. Inhibitors of UCHL5 have shown potential as anti-cancer agents by enhancing proteasomal degradation of key regulatory proteins. Knockdown studies reveal its role in impaired cell growth, defective DNA repair, and increased apoptosis, highlighting UCHL5's importance in protein homeostasis, cellular stability, and cancer progression.
Related Products
anti- UCHL5 antibody
Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.
Ver Producto
Recombinant Human UCH37
Ver Producto
Ubiquitin Carboxyl Terminal Hydrolase L5 (UCHL5) Antibody
UCHL5 Antibody is a Rabbit Polyclonal Antibody against UCHL5.
Ver Producto