Tyrosine-Protein Kinase Blk Phospho-Tyr501 (BLK pY501) Antibody

Product Graph
52€ (10 µg)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Tyrosine-Protein Kinase Blk Phospho-Tyr501 (BLK pY501) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx012594
tested applications
ELISA, IHC

Description

Rabbit polyclonal antibody against BLK protein. Immunogen region is C-terminal. Specificity is as follows for the reactive species: H:Y501, M:Y495, R:Y495.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Tyrosine-Protein Kinase Blk Phospho-Tyr501 (BLK pY501)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Assay Data
Modification: Phosphorylation // Target Modification: Tyr501
Recommended Dilution
IHC: 1/50 - 1/100, ELISA: 1/20000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.
Size 1
10 µg
Size 2
100 µg
Size 3
200 µg
Size 4
300 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA, IHC
Buffer
PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P51451
Background
Antibody anti-BLK
Status
RUO
Note
Concentration: 1 mg/ml -

Descripción

Related Products

FNab00906

BLK antibody

Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor(BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor(BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207'. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor(pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose.

Ver Producto
P5323

Recombinant Human BLK

Ver Producto
abx006945

Tyrosine-Protein Kinase BLK (BLK) Antibody

BLK Antibody is a Rabbit Polyclonal Antibody against BLK.

Ver Producto