Tyrosine Protein Kinase 7 (PTK7) Antibody
260€ (100 µl)
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Name
Tyrosine Protein Kinase 7 (PTK7) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx132153
Tested Applications
WB
Description
Tyrosine Protein Kinase 7 (PTK7) Antibody is a Rabbit Polyclonal against Tyrosine Protein Kinase 7 (PTK7).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Tyrosine Protein Kinase 7 (PTK7) Immunogen: Recombinant Tyrosine Protein Kinase 7 (PTK7) (Leu853-Pro1070) expressed in E. coli. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC (Predicted): 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | CCK4,CCK-4,Colon carcinoma kinase 4,Protein-tyrosine kinase 7,Pseudo tyrosine kinase receptor 7,Tyrosine-protein kinase-like 7,Inactive tyrosine-protein kinase 7 |
| Background | Antibody anti-PTK7 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Protein Tyrosine Kinase 7 (PTK7) is an inactive receptor tyrosine kinase that plays a critical role in cell signaling, development, and Wnt pathway regulation. Unlike other kinases, PTK7 lacks catalytic activity due to mutations in its kinase domain but functions as a co-receptor to regulate signaling pathways. Structurally, PTK7 has multiple extracellular immunoglobulin-like domains, a transmembrane region, and a pseudokinase domain. It is widely expressed during embryonic development and in adult tissues, particularly in processes involving cell polarity, migration, and morphogenesis. PTK7 is crucial for Wnt signaling, especially the non-canonical planar cell polarity (PCP) pathway, where it regulates tissue organization and cell orientation. It also modulates processes such as angiogenesis, neural development, and epithelial cell migration. PTK7 has been implicated in cancer progression, including colorectal cancer, gastric cancer, and leukemia, where it promotes metastasis, angiogenesis, and resistance to apoptosis. Altered PTK7 expression is associated with poor prognosis in cancer patients. Given its importance in development and disease, PTK7 is being explored as a therapeutic target in oncology and regenerative medicine.
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