Tyrosine Kinase 2 (TYK2) Antibody
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Description
TYK2 Antibody is a Rabbit Polyclonal antibody against TYK2. This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tyrosine Kinase 2 (TYK2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P29597 |
| Gene ID | 7297 |
| NCBI Accession | NP_003322.3 |
| Background | Antibody anti-TYK2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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Tyrosine Kinase 2 (TYK2) Antibody
TYK2 Antibody is a Rabbit Polyclonal antibody against TYK2. This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
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Tyrosine Kinase 2 (TYK2) Antibody
TYK2 Antibody is a Rabbit Polyclonal antibody against TYK2. Tyk2, a member of the Jak family of protein tyrosine kinases, associates with and is activated by receptors for many cytokines including IL-13, the IL-6 family, IL-10, and interferon-alpha and betaFollowing ligand binding, Tyk2 is activated by phosphorylation on Tyr1054 and/or Tyr1055Tyk2 is required for the tyrosine phosphorylation of Stat3 in the IFN-beta signaling cascade.
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