14-3-3 Protein Zeta/Delta (YWHAZ) CLIA Kit
845€ (96 tests)
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935106861
info@markelab.com
name
14-3-3 Protein Zeta/Delta (YWHAZ) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx495788
tested applications
CLIA
Description
Tyrosine 3/Tryptophan 5 Monooxygenase Activation Protein Zeta (YWHAZ) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Serum, plasma, tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | 14-3-3 Protein Zeta/Delta (YWHAZ) |
| Reactivity | Human, Mouse, Rat |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.116 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | YWHAZ, 14-3-3-zeta, HEL-S-3, HEL4, KCIP-1, YWHAD, HEL-S-93, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta, POPCHAS |
| Background | CLIA Kits YWHAZ |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
YWHAZ, a member of the 14-3-3 protein family, is a highly conserved adaptor protein that regulates signal transduction by binding to phosphorylated serine/threonine residues on target proteins. It functions as a molecular scaffold, facilitating protein-protein interactions involved in diverse cellular processes, including cell cycle progression, apoptosis, and signal transduction. YWHAZ plays a role in regulating pathways such as PI3K/Akt, MAPK, and TGF-β, influencing cell survival, proliferation, and migration. It is abundantly expressed in the brain and immune tissues, where it is critical for neuronal development, synaptic plasticity, and stress responses. Dysregulation of YWHAZ is implicated in neurological disorders, cancer progression, and metabolic diseases due to its role in stabilizing oncogenic and signaling proteins. Knockout studies reveal defects in brain development, increased apoptosis, and impaired cell signaling, underscoring its essential role as a key regulator of cellular homeostasis and signaling pathways.
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YWHAZ antibody
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene.
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