Tumor Necrosis Factor Receptor Superfamily Member 9 / CD137 (TNFRSF9) Antibody
299€ (0.1 mg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Tumor Necrosis Factor Receptor Superfamily Member 9 / CD137 (TNFRSF9) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx139583
tested applications
ELISA, FCM, IP, FUNC
Description
CD137 Antibody is a Mouse Monoclonal against CD137.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tumor Necrosis Factor Receptor Superfamily Member 9 / CD137 (TNFRSF9) |
| Host | Mouse |
| Reactivity | Human, Monkey |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 Kappa |
| Clone ID | L667 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | ELISA, FCM, IP, FUNC |
| Buffer | LE/AF PBS solution, 0.2 µm filter sterilized. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | Q07011 |
| Gene ID | 3604 |
| Alias | Tumor necrosis factor receptor superfamily member 9,ILA,4-1BB,CD137,CDw137,IMD109,4-1BB ligand receptor,T-cell antigen 4-1BB homolog,T-cell antigen ILA |
| Background | Antibody anti-TNFRSF9 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
TNFRSF9, also known as 4-1BB or CD137, is a member of the tumor necrosis factor receptor (TNFR) superfamily and plays a key role in immune regulation. This receptor is expressed primarily on activated T cells, as well as on natural killer (NK) cells, dendritic cells, and some other immune cell types, particularly after stimulation. It serves as a co-stimulatory receptor, enhancing T-cell proliferation, survival, and effector function, making it pivotal in immune responses and antitumor immunity. TNFRSF9 has gained attention as a therapeutic target in cancer immunotherapy due to its role in enhancing immune cell activation and persistence. Upon binding with its ligand, TNFSF9 (also known as 4-1BB ligand or 4-1BBL), TNFRSF9 undergoes trimerization, which is essential for transmitting downstream signaling. This receptor’s functions extend beyond tumor immunity; it is also involved in chronic inflammation and autoimmune diseases, and as such, modulation of TNFRSF9 signaling has therapeutic implications across several pathologies.
Related Products
Human TNFRSF9/4-1BB (Tumor necrosis factor receptor superfamily member 9) ELISA Kit
Ver Producto
Human TNFRSF9/4-1BB (Tumor necrosis factor receptor superfamily member 9) ELISA Kit
Ver Producto