Human Tumor Necrosis Factor Receptor Superfamily Member 9 / CD137 (TNFRSF9) Protein
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935106861
info@markelab.com
Precio
2249€ (1 mg)
Protein TNFRSF9
proveedor
Abbexareference
abx069572Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
TNFRSF9, also known as 4-1BB or CD137, is a member of the tumor necrosis factor receptor (TNFR) superfamily and plays a key role in immune regulation. This receptor is expressed primarily on activated T cells, as well as on natural killer (NK) cells, dendritic cells, and some other immune cell types, particularly after stimulation. It serves as a co-stimulatory receptor, enhancing T-cell proliferation, survival, and effector function, making it pivotal in immune responses and antitumor immunity. TNFRSF9 has gained attention as a therapeutic target in cancer immunotherapy due to its role in enhancing immune cell activation and persistence. Upon binding with its ligand, TNFSF9 (also known as 4-1BB ligand or 4-1BBL), TNFRSF9 undergoes trimerization, which is essential for transmitting downstream signaling. This receptor’s functions extend beyond tumor immunity; it is also involved in chronic inflammation and autoimmune diseases, and as such, modulation of TNFRSF9 signaling has therapeutic implications across several pathologies.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Tumor Necrosis Factor Receptor Superfamily Member 9 / CD137 (TNFRSF9)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
1 mg
size 2
5 mg
observerd MW
Molecular Weight: Calculated MW: 13.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asn40-Glu153 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
TNFRSF9
dry ice
No
availability
Shipped within 1-2 months.
alias
Tumor necrosis factor receptor superfamily member 9,ILA,4-1BB,CD137,CDw137,IMD109,4-1BB ligand receptor,T-cell antigen 4-1BB homolog,T-cell antigen ILA
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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