Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7) Antibody (Biotin)
377€ (200 µl)
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935106861
info@markelab.com
name
Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx272471
tested applications
WB, IHC, IF/ICC
Description
Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin against Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.5-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 200 µl |
| Size 2 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | T14,S152,Tp55,TNFRSF7,CD27 antigen,CD27L receptor,T-cell activation antigen CD27,Tumor necrosis factor receptor superfamily member 7 |
| Background | Antibody anti-CD27 |
| Status | RUO |
Descripción
CD27, also known as TNFRSF7 (tumor necrosis factor receptor superfamily member 7), is a cell surface receptor primarily expressed on T cells, B cells, and NK cells, playing a pivotal role in the regulation of immune responses. CD27 is a member of the TNF receptor superfamily and functions as a key co-stimulatory molecule, contributing to the development and survival of T lymphocytes, the formation of memory T cells, and the activation of B cells. Its ligand, CD70, also plays an essential role in immune activation, particularly in T-cell-B-cell communication. CD27 engagement through CD70 induces signaling pathways critical for T-cell activation, proliferation, differentiation, and long-term immune memory. The CD27-CD70 axis is tightly regulated because dysregulation of these pathways can lead to immune system-related diseases, including autoimmune disorders, chronic inflammation, and cancer. In addition to its role in adaptive immunity, CD27 is involved in immune surveillance and the elimination of pathogens and tumor cells. Importantly, CD27 is a target for therapeutic intervention, particularly in immunotherapy strategies aimed at boosting the immune response against cancer.
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