Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7) Antibody (APC)
637€ (100 tests)
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935106861
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name
Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7) Antibody (APC)
category
Primary Antibodies
provider
Abbexa
reference
abx270534
tested applications
FCM
Description
Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7) Antibody (APC) is a Mouse Monoclonal Antibody conjugated to APC against Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7) for use in flow cytometry.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | FCM: 1-5 µl/106 cells. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | APC |
| Isotype | IgG2b Kappa |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 100 tests |
| Size 2 | 200 tests |
| Size 3 | 500 tests |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. |
| Dry Ice | No |
| Alias | T14,S152,Tp55,TNFRSF7,CD27 antigen,CD27L receptor,T-cell activation antigen CD27,Tumor necrosis factor receptor superfamily member 7 |
| Background | Antibody anti-CD27 |
| Status | RUO |
Descripción
CD27, also known as TNFRSF7 (tumor necrosis factor receptor superfamily member 7), is a cell surface receptor primarily expressed on T cells, B cells, and NK cells, playing a pivotal role in the regulation of immune responses. CD27 is a member of the TNF receptor superfamily and functions as a key co-stimulatory molecule, contributing to the development and survival of T lymphocytes, the formation of memory T cells, and the activation of B cells. Its ligand, CD70, also plays an essential role in immune activation, particularly in T-cell-B-cell communication. CD27 engagement through CD70 induces signaling pathways critical for T-cell activation, proliferation, differentiation, and long-term immune memory. The CD27-CD70 axis is tightly regulated because dysregulation of these pathways can lead to immune system-related diseases, including autoimmune disorders, chronic inflammation, and cancer. In addition to its role in adaptive immunity, CD27 is involved in immune surveillance and the elimination of pathogens and tumor cells. Importantly, CD27 is a target for therapeutic intervention, particularly in immunotherapy strategies aimed at boosting the immune response against cancer.
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