Tumor Necrosis Factor Receptor Superfamily Member 1A / CD120a (TNFRSF1A) Antibody
299€ (0.1 mg)
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935106861
info@markelab.com
name
Tumor Necrosis Factor Receptor Superfamily Member 1A / CD120a (TNFRSF1A) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx139922
tested applications
IHC, FCM, IP, FUNC
Description
CD120a Antibody is a Mouse Monoclonal against CD120a.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tumor Necrosis Factor Receptor Superfamily Member 1A / CD120a (TNFRSF1A) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Clone ID | T387 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | IHC, FCM, IP, FUNC |
| Buffer | LE/AF PBS solution, 0.2 µm filter sterilized. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P19438 |
| Gene ID | 7132 |
| Alias | FPF,p55,p60,TBP1,TNF-R,TNFAR,TNFR1,p55-R,CD120a,TNFR55,TNFR60,TNF-R-I,TNF-R55,Tumor necrosis factor receptor superfamily member 1A,Tumor necrosis factor receptor type I |
| Background | Antibody anti-TNFRSF1A |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
TNFRSF1A , also known as Tumor Necrosis Factor Receptor Superfamily Member 1A or TNFR1 , is a prominent cell surface receptor that binds tumor necrosis factor-alpha (TNF-α). TNFR1 plays a critical role in regulating immune responses, cell survival, apoptosis, and inflammation, making it an essential component in both innate and adaptive immunity. The TNFRSF1A gene is located on chromosome 12p13.31 and encodes a protein that is expressed in nearly all cell types, with high expression in immune cells, epithelial cells, and neurons. As a member of the TNF receptor superfamily, TNFRSF1A is involved in multiple signaling pathways, depending on cellular and environmental conditions. Upon binding to TNF-α, TNFR1 can trigger both pro-inflammatory responses and cell death pathways, depending on the context of signaling and additional molecules present. This receptor’s dual role is tightly regulated, as overactivation of TNFR1-mediated pathways can lead to pathological inflammation, while insufficient TNFR1 activity may hinder immune responses.
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