Tumor Necrosis Factor Receptor Superfamily Member 13C (TNFRSF13C) Antibody (FITC)
364€ (100 tests)
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935106861
info@markelab.com
name
Tumor Necrosis Factor Receptor Superfamily Member 13C (TNFRSF13C) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx140644
tested applications
FCM
Description
Tumor Necrosis Factor Receptor Superfamily Member 13C (TNFRSF13C) Antibody (FITC) is a mouse monoclonal antibody against Tumor Necrosis Factor Receptor Superfamily Member 13C (TNFRSF13C).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tumor Necrosis Factor Receptor Superfamily Member 13C (TNFRSF13C) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | FITC |
| Isotype | IgG1 Kappa |
| Clone ID | W408 |
| Purification | The purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions. The conjugate is purified by size-exclusion chromatography. |
| Size 1 | 100 tests |
| Tested Applications | FCM |
| Buffer | Stabilizing PBS solution containing 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | Q96RJ3 |
| Gene ID | 115650 |
| Alias | Tumor necrosis factor receptor superfamily member 13C,BAFFR,CD268,CVID4,BAFF-R,BROMIX,prolixin,B-cell-activating factor receptor,BAFF receptor,BAFF-R |
| Background | Antibody anti-TNFRSF13C |
| Status | RUO |
Descripción
TNFRSF13C, also known as the B-cell activating factor receptor (BAFF-R), is a critical receptor involved in the regulation of B cell survival and maturation within the immune system. It belongs to the tumor necrosis factor receptor superfamily (TNFRSF), with BAFF-R specifically binding BAFF (B-cell activating factor), also known as TNFSF13B. BAFF-R signaling is essential for the differentiation of B cells and their progression through developmental stages, playing a crucial role in both innate and adaptive immunity. Dysfunction in TNFRSF13C signaling has been implicated in immune-related disorders, including autoimmune diseases and immunodeficiencies. Genetic mutations or dysregulation in BAFF-R and BAFF signaling pathways are associated with conditions such as Systemic Lupus Erythematosus (SLE) and Common Variable Immunodeficiency (CVID), as they can lead to abnormal B cell activity, autoreactivity, and altered antibody production. This receptor is also studied as a therapeutic target for autoimmune diseases, with strategies aimed at modulating BAFF levels to control B cell activity.
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