Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) Antibody (PE)
585€ (100 tests)
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Name
Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) Antibody (PE)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx270862
Tested Applications
FCM
Description
Tumor Necrosis Factor Receptor Superfamily, Member 10C (TNFRSF10C) Antibody (PE) is a Rabbit Polyclonal Antibody conjugated to PE against Tumor Necrosis Factor Receptor Superfamily, Member 10C (TNFRSF10C) for use in flow cytometry.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 550 Excitation/Emission: 565/575 |
| Recommended Dilution | FCM: 1-5 µl/106 cells. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | PE |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 100 tests |
| Size 2 | 200 tests |
| Size 3 | 500 tests |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. |
| Dry Ice | No |
| Alias | Tumor necrosis factor receptor superfamily member 10C,LIT,DCR1,TRID,CD263,TRAILR3,TRAIL-R3,DCR1-TNFR,Antagonist decoy receptor for TRAIL/Apo-2L,Decoy TRAIL receptor without death domain,TNF-related apoptosis-inducing ligand receptor 3 |
| Background | Antibody anti-TNFRSF10C |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
TNFRSF10C (TNF receptor superfamily member 10C), also known as TRAIL-R3 or Decoy Receptor 1 (DcR1), is part of the TNF receptor superfamily and specifically the death receptor subset involved in binding the ligand TRAIL (TNF-related apoptosis-inducing ligand). Unlike other TRAIL receptors, such as TNFRSF10A (TRAIL-R1) and TNFRSF10B (TRAIL-R2), which can initiate apoptosis upon TRAIL binding, TNFRSF10C is categorized as a “decoy” receptor. This classification is due to its structural attributes that prevent it from transmitting apoptotic signals. Instead, TNFRSF10C functions by binding TRAIL and preventing it from interacting with apoptosis-inducing receptors, thereby modulating apoptosis sensitivity in cells. TNFRSF10C is predominantly expressed in normal, non-transformed tissues, suggesting a role in protecting healthy cells from TRAIL-induced apoptosis. It has gained scientific interest due to its potential implications in cancer biology, where it may contribute to tumor resistance against TRAIL-based therapies.
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