Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) Antibody
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Description
Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) Antibody is a Mouse Monoclonal antibody against Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 100 µg |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| Alias | Tumor necrosis factor receptor superfamily member 10C,LIT,DCR1,TRID,CD263,TRAILR3,TRAIL-R3,DCR1-TNFR,Antagonist decoy receptor for TRAIL/Apo-2L,Decoy TRAIL receptor without death domain,TNF-related apoptosis-inducing ligand receptor 3 |
| Background | Antibody anti-TNFRSF10C |
| Status | RUO |
Descripción
TNFRSF10C (TNF receptor superfamily member 10C), also known as TRAIL-R3 or Decoy Receptor 1 (DcR1), is part of the TNF receptor superfamily and specifically the death receptor subset involved in binding the ligand TRAIL (TNF-related apoptosis-inducing ligand). Unlike other TRAIL receptors, such as TNFRSF10A (TRAIL-R1) and TNFRSF10B (TRAIL-R2), which can initiate apoptosis upon TRAIL binding, TNFRSF10C is categorized as a “decoy” receptor. This classification is due to its structural attributes that prevent it from transmitting apoptotic signals. Instead, TNFRSF10C functions by binding TRAIL and preventing it from interacting with apoptosis-inducing receptors, thereby modulating apoptosis sensitivity in cells. TNFRSF10C is predominantly expressed in normal, non-transformed tissues, suggesting a role in protecting healthy cells from TRAIL-induced apoptosis. It has gained scientific interest due to its potential implications in cancer biology, where it may contribute to tumor resistance against TRAIL-based therapies.
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Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) Antibody
TNFRSF10C Antibody is a Rabbit Polyclonal antibody against TNFRSF10C. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.
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