Tumor Necrosis Factor Receptor Superfamily Member 10B / DR5 (TNFRSF10B) Antibody
169€ (20 µg)
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935106861
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name
Tumor Necrosis Factor Receptor Superfamily Member 10B / DR5 (TNFRSF10B) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx302467
tested applications
ELISA, IF/ICC
Description
TNFRSF10B Antibody is a Rabbit Polyclonal against TNFRSF10B.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tumor Necrosis Factor Receptor Superfamily Member 10B / DR5 (TNFRSF10B) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IF/ICC: 1/200 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O14763 |
| Gene ID | 8795 |
| NCBI Accession | NP_003833.4, NM_003842.4, NP_671716.2, NM_147187.2 |
| OMIM | 275355 |
| Alias | DR5,CD262,KILLER,TRICK2,TRICKB,ZTNFR9,TRAILR2,TRICK2A,TRICK2B,TRAIL-R2,KILLER/DR5,Death receptor 5,TNF-related apoptosis-inducing ligand receptor 2 |
| Background | Antibody anti-TNFRSF10B |
| Status | RUO |
Descripción
TNFRSF10B (TNF receptor superfamily member 10b), also known as TRAIL-R2, DR5 (death receptor 5), or KILLER (Killer/DR5), is a cell surface receptor in the TNF receptor superfamily. It plays a crucial role in mediating apoptosis, especially in transformed or cancerous cells, through interaction with the TNF-related apoptosis-inducing ligand (TRAIL). Like other members of the death receptor family, TNFRSF10B is part of the body's natural mechanism for controlling cell growth, immune responses, and tumor suppression. TRAIL selectively targets cells exhibiting TNFRSF10B expression, making it a key pathway in immune surveillance and tumor inhibition, while leaving normal cells relatively unaffected. Due to its selective induction of apoptosis in abnormal cells, TNFRSF10B has become an important target in cancer therapeutics.
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