Tumor Necrosis Factor Receptor Superfamily Member 10B / DR5 (TNFRSF10B) Antibody

Name: Tumor Necrosis Factor Receptor Superfamily Member 10B / DR5 (TNFRSF10B) Antibody
Brand: Abbexa
SKU: abx001148
Price: 195 EUR
Availability: OnlineOnly

Este producto es parte de TNFRSF10B - TNF receptor superfamily member 10b

Pida mas información

935106861

info@markelab.com

Precio

195€ (20 µl)

Antibody anti-TNFRSF10B

proveedor

Abbexa

reference

abx001148

Tested Applications

ELISA, WB

reactivity

Human

status

RUO

clonality

Polyclonal

Descripción

TNFRSF10B Antibody is a Rabbit Polyclonal antibody against TNFRSF10B. The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.

Background

TNFRSF10B (TNF receptor superfamily member 10b), also known as TRAIL-R2, DR5 (death receptor 5), or KILLER (Killer/DR5), is a cell surface receptor in the TNF receptor superfamily. It plays a crucial role in mediating apoptosis, especially in transformed or cancerous cells, through interaction with the TNF-related apoptosis-inducing ligand (TRAIL). Like other members of the death receptor family, TNFRSF10B is part of the body's natural mechanism for controlling cell growth, immune responses, and tumor suppression. TRAIL selectively targets cells exhibiting TNFRSF10B expression, making it a key pathway in immune surveillance and tumor inhibition, while leaving normal cells relatively unaffected. Due to its selective induction of apoptosis in abnormal cells, TNFRSF10B has become an important target in cancer therapeutics.

Características del producto

clonality

Polyclonal

reactivity

Human

immunogen target

Tumor Necrosis Factor Receptor Superfamily Member 10B / DR5 (TNFRSF10B)

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

Liquid

tested applications

ELISA, WB

purification

Purified by affinity chromatography.

recommended dilution

ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.

buffer

PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol.

size 1

20 µl

size 2

100 µl

size 3

2 × 100 µl

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

TNFRSF10B

dry ice

availability

Shipped within 5-10 working days.

alias

DR5,CD262,KILLER,TRICK2,TRICKB,ZTNFR9,TRAILR2,TRICK2A,TRICK2B,TRAIL-R2,KILLER/DR5,Death receptor 5,TNF-related apoptosis-inducing ligand receptor 2

uniprot id

https://www.uniprot.org/uniprotkb/O14763

gene id

https://www.ncbi.nlm.nih.gov/gene/8795

NCBI accession

NP_003833.4

note

Concentration: > 0.2 mg/ml -

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proveedor

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reference

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reactivity

human

status

RUO

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