Tumor Necrosis Factor Receptor Superfamily Member 10A / CD261 (TNFRSF10A) Antibody
312€ (60 µl)
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935106861
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name
Tumor Necrosis Factor Receptor Superfamily Member 10A / CD261 (TNFRSF10A) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx004787
tested applications
IF/ICC
Description
TNFRSF10A Antibody is a Rabbit Polyclonal antibody against TNFRSF10A. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tumor Necrosis Factor Receptor Superfamily Member 10A / CD261 (TNFRSF10A) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O00220 |
| Gene ID | 8797 |
| NCBI Accession | NP_003835.3 |
| Alias | DR4,APO2,CD261,TRAILR1,TRAILR-1,Death receptor 4,NF-related apoptosis-inducing ligand receptor 1 |
| Background | Antibody anti-TNFRSF10A |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
TNFRSF10A (TNF receptor superfamily member 10a), also known as TRAIL receptor 1 (TRAIL-R1) or death receptor 4 (DR4), is a member of the TNF receptor superfamily. TNFRSF10A is primarily recognized for its ability to bind to TRAIL (TNF-related apoptosis-inducing ligand), a pro-apoptotic ligand that induces cell death selectively in transformed or cancerous cells. TRAIL and its receptors are part of a critical signaling axis that regulates apoptosis, especially in response to cellular stress and immune-mediated cell targeting. The receptor is expressed on the cell surface of a variety of tissues and has been implicated in numerous physiological processes, including tumor surveillance, immune response, and inflammatory regulation. Due to its ability to mediate apoptosis in abnormal cells while sparing normal cells, TNFRSF10A has gained attention in cancer research as a therapeutic target
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