Tumor Necrosis Factor Ligand Superfamily Member 13 / CD256 (TNFSF13) Antibody (Biotin)
377€ (200 µl)
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935106861
info@markelab.com
name
Tumor Necrosis Factor Ligand Superfamily Member 13 / CD256 (TNFSF13) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx272794
tested applications
WB, IHC, IF/ICC
Description
Tumor Necrosis Factor Ligand Superfamily, Member 13 (TNFSF13) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin against Tumor Necrosis Factor Ligand Superfamily, Member 13 (TNFSF13).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tumor Necrosis Factor Ligand Superfamily Member 13 / CD256 (TNFSF13) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 0.5-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 200 µl |
| Size 2 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | Tumor necrosis factor ligand superfamily member 13,APRIL,CD256,TALL2,ZTNF2,TALL-2,TNLG7B,TRDL-1,A proliferation-inducing ligand,TNF- and APOL-related leukocyte expressed ligand 2,TNF-related death ligand 1 |
| Background | Antibody anti-TNFSF13 |
| Status | RUO |
Descripción
TNFSF13, also known as APRIL (A Proliferation-Inducing Ligand), is a protein within the tumor necrosis factor (TNF) superfamily involved in immune system regulation, especially in B-cell survival, proliferation, and antibody production. This ligand, encoded by the TNFSF13 gene, binds to specific receptors on immune cells, including TACI (Transmembrane Activator and Calcium-Modulating Cyclophilin Ligand Interactor) and BCMA (B-Cell Maturation Antigen), to initiate signaling pathways that promote immune responses and sustain humoral immunity. APRIL, along with BAFF (B-cell Activating Factor), another TNF family ligand, is essential for adaptive immunity, supporting B cell maturation and differentiation. APRIL is mainly expressed by myeloid cells, such as dendritic cells and macrophages, and some types of lymphoid cells. Beyond its role in immune cell survival, APRIL has clinical significance, as its overexpression has been associated with autoimmune diseases, certain cancers, and inflammatory disorders. The APRIL/BAFF signaling pathways represent crucial targets for immunotherapy, especially in treating autoimmune diseases and B-cell malignancies.
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