Human Tumor Necrosis Factor Ligand Superfamily Member 13 / CD256 (TNFSF13) Protein
221€ (10 µg)
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name
Human Tumor Necrosis Factor Ligand Superfamily Member 13 / CD256 (TNFSF13) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx069548
tested applications
WB, SDS-PAGE
Description
Recombinant Tumor Necrosis Factor Ligand Superfamily, Member 13 (TNFSF13) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Tumor Necrosis Factor Ligand Superfamily Member 13 / CD256 (TNFSF13) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 17.6 kDa Observed MW (SDS-PAGE): 15 kDa Possible reasons why the actual band size differs from the predicted band size: 1. Splice variants. Alternative splicing may create different sized proteins from the same gene. 2. Relative charge. The composition of amino acids may affect the charge of the protein. 3. Post-translational modification. Phosphorylation, glycoslyation, methylation etc. may affect the band size. 4. Post-translational cleavage. Many proteins are synthesised as pro-proteins, and then cleaved to give the active form. 5. Polymerisation of the target protein. Dimerisation, multimerisation etc. will increase the band size observed. Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala105-Leu250 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 97% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized Reconstitute in ddH2O to a concentration of 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 100 mM NaHCO<sub>3</sub>, 500 mM NaCl, pH 8.3, containing 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O75888 |
| Gene ID | 8741 |
| OMIM | 604472 |
| Alias | Tumor necrosis factor ligand superfamily member 13,APRIL,CD256,TALL2,ZTNF2,TALL-2,TNLG7B,TRDL-1,A proliferation-inducing ligand,TNF- and APOL-related leukocyte expressed ligand 2,TNF-related death ligand 1 |
| Background | Protein TNFSF13 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
TNFSF13, also known as APRIL (A Proliferation-Inducing Ligand), is a protein within the tumor necrosis factor (TNF) superfamily involved in immune system regulation, especially in B-cell survival, proliferation, and antibody production. This ligand, encoded by the TNFSF13 gene, binds to specific receptors on immune cells, including TACI (Transmembrane Activator and Calcium-Modulating Cyclophilin Ligand Interactor) and BCMA (B-Cell Maturation Antigen), to initiate signaling pathways that promote immune responses and sustain humoral immunity. APRIL, along with BAFF (B-cell Activating Factor), another TNF family ligand, is essential for adaptive immunity, supporting B cell maturation and differentiation. APRIL is mainly expressed by myeloid cells, such as dendritic cells and macrophages, and some types of lymphoid cells. Beyond its role in immune cell survival, APRIL has clinical significance, as its overexpression has been associated with autoimmune diseases, certain cancers, and inflammatory disorders. The APRIL/BAFF signaling pathways represent crucial targets for immunotherapy, especially in treating autoimmune diseases and B-cell malignancies.
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