Transmembrane Emp24 Domain-Containing Protein 4 (TMED4) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
Transmembrane Emp24 Domain-Containing Protein 4 (TMED4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx238740
tested applications
ELISA, WB, IF/ICC
Description
TMED4 Antibody is a Rabbit Polyclonal against TMED4.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Transmembrane Emp24 Domain-Containing Protein 4 (TMED4) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IF/ICC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q7Z7H5 |
| Gene ID | 222068 |
| OMIM | 612038 |
| Alias | ERS25, GMP25iso, HNLF, p24a3, p24alpha3,Putative NF-kappa-B-activating protein 156,p24 family protein alpha-3,p24alpha3 |
| Background | Antibody anti-TMED4 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
TMED4, a key p24 family member, participates in the regulation of vesicle-mediated trafficking in the early secretory pathway, facilitating cargo transport between the ER, ER-Golgi intermediate compartment (ERGIC), and Golgi apparatus. TMED4 interacts with coat proteins (COPII and COPI) to enable vesicle budding, cargo sorting, and retrieval, ensuring protein quality control and proper trafficking dynamics. It also contributes to maintaining Golgi organization, regulating secretory pathway efficiency, and supporting protein maturation processes. TMED4 is widely expressed across various tissues, particularly in actively secreting cells, where it supports cellular homeostasis and organelle function. Dysregulation of TMED4 is associated with neurodegeneration, metabolic disorders, and cancers, where altered trafficking pathways lead to protein mislocalization and cellular stress. Knockdown studies reveal disrupted vesicle formation, increased ER stress, and impaired protein transport, underscoring its role in coordinating intracellular trafficking, protein stability, and cellular function.
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